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EFFECTS OF A DECLINE IN THE CIRCADIAN RHYTHM FUNCTION DURING THE AGING ON DAYTIME BRAIN FUNCTION

Research Project

Project/Area Number 07671095
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionNATIONAL INSTITUTE OF MENTAL HEALTH,NATIONAL CENTER OF NEUROLOGY AND PSYCHIATRY

Principal Investigator

SHIRAKAWA Shuichiro  NATIONAL INSTITUTE OF MENTAL HEALTH,N.C.N.P., DEPARTMENT OF PSYCHOGERIATRICS,RESEARCH HEAD, 精神保健研究所・老人精神保健部, 室長 (20100141)

Co-Investigator(Kenkyū-buntansha) UCHIYAMA Makoto  NATIOAL INSTITUTE OF MENTAL HEALTH,N.C.N.P., DEPARTMENT OF PSYCHOPHYSIOLOGY,RESE, 神経センター・精神保健研究所・精神生理部, 室長 (20221111)
OKAWA Masako  NATIONAL INSTITUTE OF MENTAL HEALTH,N.C.N.P., DEPARTMENT OF PSYCHOPHYSIOLOGY,DIR, 神経センター・精神保健研究所・精神生理部, 部長 (80160430)
小栗 貢  東邦大学, 理学部, 教授 (60120250)
亀井 雄一  国立精神, 神経センター・精神保健研究所, 研究員 (60233970)
Project Period (FY) 1995 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1997: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1996: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1995: ¥1,200,000 (Direct Cost: ¥1,200,000)
KeywordsINSOMNIA / CIRCADIAN RHYTHM / AGED PEOPLE / CORE BODY TEMPERATURE / ACTIVITY / MOTIVATION / NAP SLEEP / 深部体温 / 老年者 / 社会的適応度 / 睡眠・覚醒リズム / 体温リズム / 睡眠障害
Research Abstract

We reported in 1996 that over 15% of the aged people in Japan had the persistent insomnia. The brain function and mental health in the aged having persistent insomnia was disturbed. A decline in the amplitude of circadian rhythm estimated by core body temperature measurement of the aged having persistent insomnia was observed. We discovered a drastic improvement effects of the short time nap sleep in the acrophase of body temperature circadian rhythm on the nighttime sleep qualities by the survey. Six aged subjects having persistent insomnia were given 30 minutes of the scheduled daytime nap sleep and continuously monitored the sleepwake states estimated by the activities. The nap sleep in the acrophase of body temperature circadian rhythm decreased the wake-time after sleep onset and the inversion of sleep during the sun down phase. The sleep feelings in the aged having persistent insomnia were improved by the acquisition of short time nap sleep.

Report

(4 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • 1995 Annual Research Report
  • Research Products

    (53 results)

All Other

All Publications (53 results)

  • [Publications] 白川 修一郎: "睡眠不足の健康への影響" 治療. 77・8. 120-121 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 白川 修一郎 他: "睡眠覚醒リズムの老化" 臨床精神医学. 24・6. 661-670 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 亀一 雄一 白川 修一郎: "臨床障害の検査方法" 陸将精神医学. 24・7. 985-995 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 白川 修一郎 他: "老年者のサーカディアンリズム" 日本薬剤師会雑誌. 48. 341-350 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 前田 素子、有富 良二、白川 修一郎: "サラリーマンの睡眠の特徴と睡眠・覚醒リズムの加齢変化" 睡眠と環境. 3. 103-107 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 白川 修一郎: "老人のサーカディアンリズムの特徴" '95国際長寿科学シンポジウム記録集. 231-237 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 白川 修一郎: "老年者の睡眠障害-そのしくみと対処法" 音楽心理学音楽療法研究年報. 25. 37-46 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 白川 修一郎: "高齢者・痴呆性老人の睡眠と生体リズム(1)" ヘルシー・ミュージック. 263. 4-10 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 白川 修一郎: "高齢者・痴呆性老人の睡眠と生体リズム(2)" ヘルシー・ミュージック. 264. 10-13 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 白川 修一郎: "入眠を促進する高齢者のライフスタイル" 第6回日本睡眠環境学会大会報告集. 48-52 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 鍛冶 恵.有富 良二.白川 修一郎: "都市部サラリーマンの睡眠習慣と睡眠環境" 第6回日本睡眠環境学会大会報告集. 14-17 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 白川 修一郎: "発達、老化と睡眠" ブレインナーシング. 13. 430-436 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 白川 修一郎: "睡眠衛生" ブレイナーシング. 14. 166-171 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 白川 修一良: "高齢者の睡眠" 睡眠と環境. 4・1. 44-50 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 城田 愛、田中 秀樹、林 光緒、白川 修一郎、堀 忠夫: "高齢者の意欲的なライフスタイルと活動-休止リズム" 生理心理. 15・2. 53-60 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 白川 修一郎、高瀬 美紀: "睡眠障害と健康被害・経済損失" 臨床と薬物治療. 17・3. 222-226 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 白川 修一郎、高橋 清久: "睡眠障害に関する疫学的事項" 日本臨床. 56・2. 475-481 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 白川 修一郎、一瀬 邦弘: "老人のせん妄、睡眠覚醒リズム障害とその治療、日本生物学的精神医学会編 生体リズムと精神疾患" 学会出版センター,東京, 71-93 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 白川 修一郎: "高齢者の眠りの調節、鳥居鎮夫編:睡眠環境の科学" 朝倉書店、東京 (印刷中), (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 白川 修一郎: "老人の睡眠障害、高橋徹、設楽信行、清水輝夫編:最新 脳と神経科学シリーズ 第10巻睡眠とその障害" メジカルビュー社、東京 (印刷中), (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 白川 修一郎: "その他の時間生物学的治療と睡眠衛生、岸本朗、井上雄一編:精神科治療の理論と技法-薬物療法と生理学的治療-" 星和書店、東京 (印刷中), (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shirakawa S,Kitado M,Kamei Y,Maeda M,Hirose K,Okawa M: "Sleep-wake rhythm during aging." Jap J Clin Psychiatr. 24 (6). 661-670 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kamei Y,Shirakawa S: "Monitoring in the diagnostic and therapeutic assessment of sleep disorders." Jpa J Clin Psychiatr. 24 (7). 985-995 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shirakawa S: "Bad influence of sleep disturbance on the health." J Therap. 77 (8). 120-121 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shirakawa S,Ishizuka Y,Okawa M: "Circakian rhythm in the aged." J Japan Pharmaceutical Association. 48 (3). 341-350 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Maeda M,Aritomi R,Shirakawa S: "Characteristics of sleep in daytime workers and changes of sleep-wake rhythm during aging." Sleep and Environments. 3 (1). 103-107 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shirakawa S: "Characteristics of circadian rhythm in the aged" '95 Nagoya International Symposium on Aging and Health. 231-237 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shirakawa S: "Sleep disorders in the aged : mechanisms and therapy." The Annual of Music Psycology and Therapy. 25. 37-46 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shirakawa S: "Sleep and biological rhythm in the aged and aged dementia (1)." Healthy music. 263. 4-10 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shirakawa S: "Sleep and biological rhythm in the aged and aged dementia (2)." Healthy music. 264. 10-13 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shirakawa S,Ichise K: "Delirium and Sleep-Wake Rhythm Disorders in the Aged and Treatment." In : Biological Rhythm and Psychiatric Disorders (Japanese Society of Biological Psychiatry, Mikuni M,Takahashi K eds). Gakkai Shuppan Center, Tokyo. 71-93 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shirakawa S: "The life style having good sleep in the aged." Reports of the 6th meeting of Japanese Society of Sleep and Environments. 48-52 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kaji M,Aritomi R,Shirakawa S: "Sleeping habits and environments in the middle aged workers living cities." Reports of the 6th meeting of Japanese Society of Sleep and Environments. 14-17 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shirakawa S,Kamei Y,Nakajima T,Otsuka Y,Watanabe M: "Sleep and aging." Sleep and Environments. 4 (1). 44-50 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shirakawa S: "Characteristics of sleep during growing and aging." Brain Nursing. 13 (5). 430-436 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shirakawa S,Takase M: "Sleep hygiene." Brain Nursing. 14 (2). 166-171 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shirakawa S,Takase M: "Sleep disorders, healthy cost and society Cost." Clinics and Drug Therapy. 17 (3). 222-226 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shirakawa S,Takahashi K: "Epidemiology of sleep disorders." Japan J Clinical Medicine. 56 (2). 475-481 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shirakawa S: "Sleep Management in the Aged." In : Science of Sleep Environment (Torii S ed). Asakura Shoten, Tokyo (in printing). 188-196 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shirakawa S: "Sleep Disorders in the Aged." In : Sleep and Sleep Disorders (Takahashi T,Shidara N,Shimizu T eds). Medical View, Tokyo (in printing). (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shirakawa S: "Chronotherapy and Sleep Hygiene." In : Principal and Practice of Psychiatric Treatments (Kishimoto A,Inoue Y eds). Seiwa Shoten, Tokyo (in printing). (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 白川修一郎 他: "高齢者の睡眠" 睡眠と環境. 4・1. 44-50 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 白川修一郎: "睡眠の役割" ブレインナーシング. 13・3. 245-249 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 白川修一郎: "発達、老化と睡眠" ブレインナーシング. 13・5. 430-436 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 鍛冶恵,有富良二,白川修一郎: "都市部サラリーマンの睡眠習慣と睡眠環境" 第6回日本睡眠環境学会大会報告集. 14-17 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 白川修一郎: "入眠を促進する高齢者のライフスタイル" 第6回日本睡眠環境学会大会報告集. 48-52 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 白川修一郎: "睡眠衛生" ブレインナーシング. 14・2. 166-171 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 白川修一郎,高橋清久: "睡眠障害に関する疫学的事項" 日本臨床. 56・2. 475-481 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 白川修一郎,高瀬美紀: "睡眠障害と健康被害・経済損失" 臨床と薬物治療. 17・3. 222-226 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 白川修一郎: "老年者のサーカディアンリズム" 日本薬剤師会雑誌. 48. 341-350 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 白川修一郎: "老年者の睡眠障害-そのしくみと対処法" 音楽心理学療法研究年報. 25. 37-46 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 白川修一郎: "睡眠不定の健康への影響" 治療. 77. 120-121 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 白川修一郎、石束嘉和、大川匡子: "老年者のサーカディアンリズム" 日本薬剤師会雑誌. 48. 341-350 (1996)

    • Related Report
      1995 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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