| Project/Area Number |
07671275
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Kobe University |
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Principal Investigator |
UETANI Yoshiyuki School of Medicine, Kobe University, Assistant Professor, 医学部, 助教授 (40168620)
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| Co-Investigator(Kenkyū-buntansha) |
TAKADA Satoshi School of Medicine, Kobe University, Lecturer, 医学部附属病院, 講師 (10216658)
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| Project Period (FY) |
1995 – 1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 1996: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 1995: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | premature infants / growth / IGF-II / IGF-I / growth factor / nutrition / intrauterine growth |
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| Research Abstract |
To clarify the effect of maternal protein nutritional status on fetal growth, low protein diet was loaded for the pregnant rats and plasma IGF-I,II of the mother rats were determined. Plasma IGF-I levels of low protein loaded mothers were significantly decreased compared to control the control group, but IGF-II levels were not different from those of control.
Plasma IGF-II levels of premature infants and cord blood were determined to study about the effects of IGF-II on the growth of premature infants after birth. The IGF-II levels of cord blood were significantly higher than those of the premature infants after birth whose postcoceptional ages were fitted. In AFD (appropriate for date) infants, IGF-II levels were depended on gestational age, but IGF-II of SFD (small for date) infants were lower than those of AFD infants. The infants normally grown at term of postconceptional week were higher in average plasma IGF-II levels thanthe infants of growth retardation. The growth rates and the growth speeds were not corelated with the IGF-II levels at term, but the body weights and heights at term corelated with plasma IGF-II levels.
These results indicate that IGF-II has the important role on the intrauterine growth through the nutritional condition and IGF-II has the role on the postnatal growth and stature of premature infants. The further studies are needed to reveal the switching mechanism from IGF-I to IGF-II during perinatal period.
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