| Project/Area Number |
07671293
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
General surgery
|
|---|
| Research Institution | UNIVERSITY OF TOKYO |
|---|
Principal Investigator |
ARAMOTO Haruo (1996) University of Tokyo, Surgery, Assistant, 医学部・附属病院, 助手 (30281702)
布川 雅雄 (1995) 東京大学, 医学部(病), 助手 (50270880)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KOMIYAMA Takashi University of Tokyo, Surgery, Assistant, 医学部・附属病院, 医員
YASUHARA Hiroshi University of Tokyo, Surgery, Lecturer, 医学部・附属病院, 講師 (50251252)
SHIGEMATSU Hiroshi University of Tokyo, Surgery, Lecturer, 医学部・附属病院, 講師 (40134556)
折口 信人 東京都老人総合研究所, 研究員
新本 春夫 東京大学, 医学部(病), 医員
|
|---|
| Project Period (FY) |
1995 – 1996
|
| Project Status |
Completed (Fiscal Year 1996)
|
| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1996: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1995: ¥1,500,000 (Direct Cost: ¥1,500,000)
|
|---|
| Keywords | critical limb ischemia / diabetes / anastomotic intimal hyperplasia / vascular graft / 血行再建術 |
|---|
| Research Abstract |
With NZW-rabbit, after severely poor run-off (bilateral iliac arteries ligation) and artificial graft reconstruction surgery, we encounterd many early deaths owing to early graft occlusion. For long-term observation, we had to find the toleratedly reduced run-off models. We compared different poor run-off states in 4 groups ; unilateral femoral artery ligation (A), bilateral femoral arteries ligation (B), unilateral femoral+contra-lateral iliac arteries ligation (C) and bilateral iliac arteries ligation with autovein graft reconstruction for long-term patency. Since, group A developed only slight run-off reduction, and in group C and D,we recognized almost as many deaths as severely poor run-off models, we selected group B as the best model.
B)Hemodynamic change between two-stage operations
Even though group B model appeared the best model, we had to add two stage surgery for long survival. In 1 week interval model, there was still high prevalence of early deaths. In 2 or 4 weeks interval models the early deaths enough reduced but unexpected development of collateral pathways was recognized as the interval became longer. We concluded the best interval for 2 stage surgery was 2 weeks.
|
