| Project/Area Number |
07671312
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
TOMITA Yukihiro Kyusyu Univ.Cardiovasc Surg.Assistant Prof, 医学部, 助手 (90180174)
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| Co-Investigator(Kenkyū-buntansha) |
FUKUMURA Fumio Kyusyu Univ.Cardiovasc Surg.Assistant Prof, 医学部, 助手 (80264026)
松崎 吾朗 九州大学, 生体防御医学部研究所, 助手 (30229455)
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| Project Period (FY) |
1995 – 1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 1996: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 1995: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | Cyclophosphamide / drug induced tolerance / Major Histocompatibility (MHC) / chimera / clonal deletion / Cyclophosphamide / キメリズム / 薬剤誘導性免疫寛容 / デストラクション / 皮膚移植 / 生着延長 |
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| Research Abstract |
From analysis performed in 1995, the following results were obtained. 1) Chimerism was induced only in lymphocytes, and wasn't induced in bone marrow level. 2) In the combination of B10D2 and B10 (MHC alone disparate), clonal destruction was observed, but the induction of chimerism was transient, and 3) skin graft survival prolongation and duration of chimeric state had significnat relationship.
From 1996, we started the analysis of our new protochol (SC+CP+Busulfan+Bone marrow cells protochol) to break through the MHC obstacle. We got very encouraging data that permanent chimerism and skingraft survaival were observed by using busulfan with our traditional CP induced tolorance protochol.
The final goal that we want to achive is to induce tolerance only by drugs in large animals. And we think our new data is going to be a greater success.
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