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Studies on Lymph Coagulation and Fibrinolysis system and Characteristics of Lymphatic Endothelium in Human

Research Project

Project/Area Number 07671317
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionKagoshima University

Principal Investigator

YAMAZUMI Kensuke  University Hospital, Research Associate, 医学部・附属病院, 助手 (40260749)

Co-Investigator(Kenkyū-buntansha) AIKOU Takashi  Kagoshima University, Faculty of Medicine, Professor, 医学部, 教授 (60117471)
夏越 祥次  鹿児島大学, 医学部・附属病院, 助手 (70237577)
Project Period (FY) 1995 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1997: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1996: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1995: ¥700,000 (Direct Cost: ¥700,000)
KeywordsLymph / Lymphatic endothelium / Thoracic duct / リンパ液
Research Abstract

Although fibrin gel formation in lymph is well-known under some condition, the role of the hemostatic system has not been elucidated.
In this project, we investigated not only the components of lymph coagulation and fibrinolysis factors, but also the characteristics of lymphatic endothelium in human. The antigen levels of fibrinogen, antithrombin III,protein C,plasminogen, tissue type plasminogen activator, thrombomodulin, alpha 2-plasmin inhibitor and free form of tissue factor pathway inhibitor in lymph were significantly lower than those in plasma, respectively. Especially, the values of fibrinogen in lymph were 150 (]SY.+-。[) 91mg/dl (mean (]SY.+-。[) SD), suggesting that the delayd fibrin gel formation in lymph results from the low concentration of fibrinogen.
On the other hand, we recognized not only the significant higher levels of urokinase type plasminogen activator in lymph than in plasma, but also the localization of urokinase type plasminogen activator onlymphatic endothelium (thracic duct) from the findings of immunohistochemical studies.

Report

(4 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • 1995 Annual Research Report
  • Research Products

    (21 results)

All Other

All Publications (21 results)

  • [Publications] 山角 健介: "フィブリノゲン異常症" 臨床医. 62. 1668-1672 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 山角 健介: "血管壁への白血球粘着とフィブリノゲン" 血液・腫瘍科. 32. 147-150 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 山角 健介: "フィブリノゲン異常症" 血液・腫瘍科. 31. 20-26 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 山角 健介: "合成ペプチドを応用したフィブリン重合機転の解析" 日本血栓止血学会誌. 8. 75-83 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] KENSUKE YAMAZUMI: "An activated state of blood coagulation and tibrimolysis in patients with AM" American Journal of Surgery. (印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kensuke Yamazumi: "Abnormal fibrinogen." Medical Clinics of Japan. 62. 1668-1672 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kensuke Yamazumi: "Leukocyte adhesion to vascular endothelium and fibtinogen." Hematology and Oncology. 31. 147-150 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kensuke Yamazumi: "Abnormal fibrinogen." Hematology and Oncology. 32. 20-26 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kensuke Yamazumi: "Analysis of fibrin polymerization by synthetic peptides." Japanese Journal of Thrombosis and Hemostasis. 8. 75-83 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kensuke Yamazumi: "An activated state of blood coagulation and fibrinolysis in patients with" American Journal of Surgery. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 山ずみ 健介: "合成ペプチドを応用したフィブリン重合機転の解析" 日本血栓止血学会誌. 8. 75-83 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 山ずみ 健介: "腎尿路系疾患の検査-フィブリノペプチドBβ15-42" 腎と透析. 43. 389-390 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 山ずみ 健介: "腎尿路系疾患の検査-プロトロンビンフラグメント1+2" 腎と透析. 43. 385-386 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 山ずみ 健介: "APIを基準にしたASOの診療の実際" 血栓と循環. 5. 286-287 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] KENSUKE YAMAZUMI: "An activated state of blood coagulation and fibrinolysis in patients with AAA" American Journal of Surgery. (印刷中).

    • Related Report
      1997 Annual Research Report
  • [Publications] 山角健介: "フィブリノゲン異常症" 血液・腫瘍科. 32. 20-26 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 山角健介: "Bβ-フラブメント" 臨床検査. 40(11). 170-171 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 山角健介: "フィブリノゲン臨床応用の現状" 臨床病理. 104. 37-40 (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] 山角健介: "合成ペプチドを応用したフィブリン重合機転の解析" 日本血栓止血学会誌. (印刷中).

    • Related Report
      1996 Annual Research Report
  • [Publications] 山角健介: "フィブリノゲン異常症" 臨床医. 62. 1668-1672 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 山角健介: "血管壁への白血球粘着とフィブリノゲン" 血液・腫瘍科. 31. 147-150 (1995)

    • Related Report
      1995 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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