| Project/Area Number |
07671343
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Kansai Medical University, Faculty of Medicine |
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Principal Investigator |
KUSUMOTO Kenji Kansai Med.Univ., Plast.Surg., Associate Professor, 医学部, 助教授 (20161630)
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| Co-Investigator(Kenkyū-buntansha) |
OGAWA Yutaka Kansai Med.Univ., Plast.Surg., Professor, 医学部, 教授 (70026912)
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| Project Period (FY) |
1995 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1997: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1996: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1995: ¥800,000 (Direct Cost: ¥800,000)
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| Keywords | Bone morphogenetic protein / osteoinduction / carrier / atelopeptide type I collagen / osteogenesis / skeletal reconstruction / 骨形式因子 / 骨形成因子(BMP) / コラーゲン / ハイドロキシアパタイト |
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| Research Abstract |
Atelopeptide type I collagen (CL) and porous hydroxyapatite (pHAP) were used as a carrier for heterotopic osteoinduction by BMPs, purified BMP,rhBMP-2 and rxBMP-4/7 heterodimer.
In using CL,purified BMP and rhBMP-2 osteoinduced ectopic bone in rat calf muscle (Kusumoto et al.BBRC 1995). However, massive trabeculum in purified BMP groups and massive marrow in rhBMP-2 groups were induced.
In using CL and pHAP,rhBMP-2 induced ectopicly in rat calf muscle (Kusumoto et al.J Cranio-Maxillofac Surg 1996). Trabeculum was induced in the pores of pHAP,even in the deep pores, and the amount was dependent upon the dosage of rhBMP-2.
In using CL,rhBMP-2 and rxBMP-4/7 heterodimer induced ectopic bone (Kusumoto et al.BBRC 1997). The amount of trabeculum in rhBMP-2 group was more than in rxBMP-4/7 heterodimer. Osteoinducing ability in rhBMP-2 gorup was vigorous than in rxBMP-4/7 heterodimer group.
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