| Project/Area Number |
07671350
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | ASAHIKAWA MEDICAL COLLEGE |
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Principal Investigator |
KONO Toru Asahikawa Medical College, Assistant, 医学部, 助手 (60215192)
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| Co-Investigator(Kenkyū-buntansha) |
KAKISAKA Akitoshi Asahikawa Medical College, Assistant, 医学部, 助手 (60194677)
MIYATA Masanobu Asahikawa Medical College, Assistant Professor, 医学部, 講師 (90174193)
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| Project Period (FY) |
1995 – 1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1996: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1995: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | cancer of the rectum / autonomous nerve preservation operation / interposition nerve grafts auto-transplantation / tetanus toxin C fragment / bladder function / 骨盤内臓神経 / 腓腹神経 / 骨盤内自律神経機能 / 神経自家移植 / 骨盤内蔵神経 / 自律神経機能温存 / 神経細胞追跡標識物質 / 免疫神経組織化学的手法 / 電気生理学的手法 |
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| Research Abstract |
Aim
By surgery treatment of cancer of the rectum discovered early comparatively, the autonomous nerve preservation operation in the pelvis which considered function maintenance after operation is recommended, but there is the case that curability of cancer is thought about in the advanced case, and cannot but abandon preservation operation currently. This study is a fundamental study to make clear the propriety of new operation method development letting a function after advaned cancer operation maintains by using an interposition nerve grafts auto-transplantation.
Methods and Results
(1) In the graft group, tetanus toxin C fragment (transsynaptic retrograde transporter) was apllied to the bladder wall with a purpose to confirm the regeneration which was occured via the grafted nerve. After 2 or 3 weeks, parasympathetic nerve cells in lower spinal cord (S2-4) were retrogradely stained by tetanus toxin C fragment via the transplanted and reproducted nerve.
(2) After 2 or 3 weeks, the recovered bladder function wasn't recognized.
(3) After 5 or 6 weeks, the function recovery preservation was recognized and was almost near by bladder function in normality.
Summary
I was able to suggest the possibility that an interposition nerve grafts auto-transplantation was extremely useful for function recovery after operation in advanced rectal cancer patients.
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