| Project/Area Number |
07671427
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
HANGU Nobuyoshi Jikei Univ School of med.surgery, assistant professor, 医学部, 講師 (30189592)
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| Co-Investigator(Kenkyū-buntansha) |
NISHIKAWA Katsunori Jikei Univ school of med.surgery, assistant, 医学部, 助手 (70246429)
AOKI Hiroshi Jikei Univ school of med.surgery, assistant, 医学部, 助手 (60266583)
FURUKAWA Yoshiyuki Jikei Univ school of med.surgery, instructor, 医学部, 講師 (80209171)
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| Project Period (FY) |
1995 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1997: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1996: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1995: ¥800,000 (Direct Cost: ¥800,000)
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| Keywords | SCFA / experimental colitis / gastrointestinal motility / 創傷治癒 / 炎症性大腸疾患 |
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| Research Abstract |
Short Chain Fatty Acids (SCFA) mainly consisting of acetate, butyrate and propionate are the major fecal solutes in the normal colon and are produced by bacterial fermentation of dietary fiber, and its efficacy is now being keenly investigated wide-ranging. In the present study, we investigated the application of SCFA to gastrointestinal surgery and obtained the following results. 1) SCFA may strengthen intestinal anastomosis after its administration, as the colonic anastomosis had the mean bursting pressure of 380mmHg in th SCFA-treated group and 190mmHg in the non-teated group in a rat model with transection and anastomosis. 2) A dog model of experimentally extened lymphadenectomy was performed to investigate the cause and the therapeutic effects on gastrointestinal dysfunction after extened lymphadenectomy in gastrointestinal cancer. Resulting in the possible interference of extrinsic nerves as a cause of postoperative gastrointestinal motility dysfunction but no clear improvement of effects after intraluminal infusion of SCFA to the intestine as a treatment were found. 3) Effects of intraluminal infusion of SCFA were investigated in the experimental colitis model using a dog. As a result, SCFA-treated group made more rapid recovery to the damaged colonic mucosa than non-treated group. Considering the result shown in 1), the efficacy of SCFA to the damaged colonic mucosa might be due to its direct effects on the colonic mucosa. On the other hand, susupected the symptoms such as frequent mucous and bloody stool and tenesmus, etc.were evidently attributable to the changes in the colonic motility in view of the recorded gastrointestinal motility.
From our results stated above, SCFA has the potential for clinical application in the field of gastrointestinal surgery as we observed more marked repairing effects on mucosa than effects on gastrointestinal motility.
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