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GENETIC POLYMORPHISM ANLYSIS OF THE CANCER RELATED GENES AND CANCER SUCEPTIBILITY

Research Project

Project/Area Number 07671432
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionNIPPON MEDICAL SCHOOL

Principal Investigator

KATO Shunji  NIPPON MEDICAL SHCOOL FIRST DEPT.OF SURGERY ASSISTANT PROFESSOR, 医学部, 助手 (60224507)

Project Period (FY) 1995 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1996: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1995: ¥1,400,000 (Direct Cost: ¥1,400,000)
KeywordsGENETIC POLYMORPHISM / CYTOCHROME P450 2E1 / CYTOCHROME P450 1A1 / L-myc PROTOONCOGENE / CANCER SUSCEPTIBILITY / DNA ADDUCT / チトクロームp450E1 / GSTM1遺伝子
Research Abstract

Research results are summarized as following :
a. For case-controls study subjects, DNA was collected from over 500 gastric cancer, 70 esophageal cancer, 80 liver cirrhosis and hepatocellular carcinoma, 70 breast cancer cases, and over 700 healthy controls.
b. Genetic polymorphism analysis was performed to find the relationship between cytochrome p450 2E1,1A1, glutathione-S-transferase M1 specific genotypes and gastric cancer of hepatocellular carcinoma.
c. Limited associations between CYP2E1 Rsa1 RFLP and hepatocellular carcinoma, between CYPlA1 Exon7 RFLP and gastric cancer were observed in this study (Pharmacogenetics, Cancer, Therapeutic Research, Biomedicine & Pharmacogenetics).

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • Research Products

    (27 results)

All Other

All Publications (27 results)

  • [Publications] Shunji Kato,et al: "Cytochrome P4502E1 (CYP2E1) genetic polymorphism in a case-control study of gastric cancer and liver disease" Pharmacogenetics. 5. 141-144 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kato S.et al: "Genetic and Environmental Risk Factors for the Gastric Cancer" 1st Internal Gastric Cancer Congress (ed Nishi et al). 385-389 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Shunji Kato,et al: "Human Lung Carcinogen-DNA Adduct Levels Mediated By Genetic" J Nat Cancer Inst. 87. 902-907 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 加藤俊二、他: "Helicobacter pylori感染と胃粘膜萎縮および胃発癌に関する遺伝子の多型性分析:分子疫学的手法による解析" 消化器癌の発生と進展. 7. 129-132 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Shunji Kato et al: "Genetic Polymorphisms of the Cancer Related Gene and Helicobacter pylori Infection in Japanese Gastric Cancer Patients : An Age and Gender Matched Case-Control Study" Cancer. 77. 1654-1661 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 加藤俊二、他: "萎縮性胃炎、腸上皮化生、胃癌SEQUENCEにおけるHelicobacter pylori感染と遺伝子多型性分析" Theapeutic Research. 17. 4232-4238 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 加藤俊二、山下精彦: "宿主因子(遺伝的素因)と病気:遺伝子の多様性による宿主側の因子からみた癌や疾病の発生" 東京都医師会雑誌. 49. 67-69 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 加藤俊二、他: "「Mitomycin C-DNA複合体の体内分布(臓器分布)と経時的変化:ヒトおよびラット正常組織におけるMitomycin Cの影響」" 癌と化学療法. 23. 1031-1037 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kato S.,et al: "Genetic polymorphisms of cancer related-genes for gastric and esophageal carcinogenesis" Recent Advances in Gastro-enterological Carcinogenesis I (ed. E. Tahara). 317-320 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kato S.,et al: "Helicobacter pylori infection and genetic polymorphisms for cancer-related genes in gastric carcinogenesis" Biomedicine & Pharmaco-therapy. (In press). (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Shunji Kato, et al: "Cytochrome P4502E1 (CYP2E1) genetic polymorphism in a case-control study of gastric cancer and liver disease" Pharmacogenetics. 5. 141-144 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kato S,et al: "Genetic and Environmental Risk Factors for the Gastric Cancer" 1st Internal Gastric Cancer Congress (ed.Nishi et al). 385-389 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Shunji Kato, et al: "Human Lung Carcinogen-DNA Adduct Levels Mediated By Genetic Polymorphisms In Vivo" J Nat Cancer Inst. 87. 902-907 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Shunji Kato, et al: "Genetic Polymorphisms of the Cancer Related Gene and Helicobacter pylori Infection in Japanese Gastric Cancer Patients" An Age and Gender Matched Case-Control Study Cancer. 77. 1654-1661 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kato S., et al: "Genetic polymorphisms of cancer related-genes for gastric and esophageal carcinogenesis" Recent Advances in Gastroenterological Carcinogenesis I (ed.E.Tahara). 317-320 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kato S., et al: "Helicobacter pylori infection and genetic polymorphisms for cancer-related genes in gastric carcinogenesis" Biomedicine & Pharmacotherapy. (in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Shunji Kato,et al: "Genetic Polymorphisms of the Cancer Related Gene and Helicobacter pylori Infection in Japanese Gastric Cancer Patients : An Age and Gender Matched Case-Control Study" Cancer. 77. 1654-1661 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 加藤俊二、その他: "萎縮性胃炎、腸上皮化生、胃癌SEQUENCEにおけるHelicobacter pylori感染と遺伝子多型性分析" Theapeutic Research. 17. 4232-4238 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 加藤俊二、山下精彦: "宿主因子(遺伝的素因)と病気:遺伝子の多様性による宿主側の因子からみた癌や疾病の発生" 東京都医師会雑誌. 49. 67-69 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 加藤俊二、その他: "「Mitomycin C-DNA複合体の体内分布(臓器分布)と経時的変化:ヒトおよびラット正常組織におけるMitomycin Cの影響」" 癌と化学療法. 23. 1031-1037 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kato S.,et al: "Genetic polymorphisms of cancer related-genes for gastric and esophageal carcinogenesis" Recent Advances in Gastro-enterological Carcinogenesis I (ed.E.Tahara). 317-320 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kato S.,et al: "Helicobacter pylori infection and genetic polymorphisms for cancer-related genes in gastric carcinogenesis" Biomedicine & Pharmaco-therapy. (in press). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Shunji Kato,et al: "Cytochrome P4502E1 (CYP2E1) genetic polymorphism in a case-control study of gastric cancer and liver disease" Pharmacogenetics. 5. 141-144 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Kato S.et al: "Genetic and Environmental Risk Factors for the Gastric Cancer" 1st Internal Gastric Cancer Congress(ed Nishi et al). 385-389 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Shunji Kato et al: "Human Lung Carcinogen-DNA Adduct Levels Mediated By Genetic Polymorphisms In Vivo." J Nat Cancer Inst. 87. 902-907 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 加藤俊二: "Helicobacter pylori感染と胃粘膜萎縮および胃発癌に関する遺伝子の多型性分析:分子疫学的手法による解析" 消化器癌の発生と進展. 7. 129-132 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Shunji Kato: "Genetic Polymorphisms of the Cancer Related Gene and Helicobacter pylori Infection in Japanese Gastric Cancer Patients" Cancer. (in press). (1996)

    • Related Report
      1995 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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