| Project/Area Number |
07671451
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Gunma University |
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Principal Investigator |
ISHIKAWA Susumu The second department of surgery, Gunma university school of medicine The associate professor, 医学部, 講師 (90241877)
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| Co-Investigator(Kenkyū-buntansha) |
OHTAKI Akio The second department of surgery, Gunma university school of medicine The resear, 医学部, 助手 (80241876)
MORISHITA Yasuo The second department of surgery, Gunma university school of medicine The chairm, 医学部, 教授 (40145470)
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| Project Period (FY) |
1995 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 1997: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1996: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1995: ¥700,000 (Direct Cost: ¥700,000)
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| Keywords | Splanchnic perfusion / Open-heart surgery / Cardiopulmonary bypass / Gastric intramucosal pH / Hepatic venous oxygen saturation |
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| Research Abstract |
To determine splanchnic perfusion after cardiopulmonary bypass, gastric intramucosal pH (pHi) and hepatic venous oxygen saturation (S_<HV>O_2) were measured in patients following open-heart surgery. Blood samples were analyzed at 6,12 and 24 hours after the admission to an intensive care unit (ICU). The results were as follows : 1)Gastric pHi increased significantly (p<0.01) from 7.21 at 6 hours to 7.31 at 12 hours and recovered to 7.37 at 24 hours, 2)S_<HV>O_2 increased significantly (p<0.05) from 48% at 6 hours to 57% at 12 hours and 24 hours, and 3)cardiac index was more than 4 L/min/m^2 and mixed venous oxygen saturation was over 70%. Despite sufficient cardiac output, splanchnic perfusion decreased after cardiopulmonary bypass and it recovered within 24 hours afrer admission to an ICU.In conclusion, gastric pHi and S_<HV>O_2 are useful parameters for postoperative splanchnic perfusion in patients with open-heart surgery.
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