| Budget Amount *help |
¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 1996: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1995: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Research Abstract |
At present, RVAD is commonly used for a right ventricular failure (RVF). In clinic, RVF patients usually suffer poor gas exchange due to cardiac failure. The purpose of this study is whether pumpless ECMO in right ventricle (RV) to left atrium (LA) bypass could be useful as a means of a treatment for a chronic RVF.Experiment I.Ten mongrel dogs (2.5-6.0 kg, mean 3.9kg) were performed banding of the main pulmonary artery (mPA), aimed for RVF due to pulmonary hypertension.
A pressure study of the right heart was performed after a long term raising (97-205 days, mean 160 days). All the cases showed the mean RV pressure (m-RVP) [mmHg] >=20 (average 30.2(]SY.+-。[)9.0 mmHg).
Experiment II.Implantation of the artificial lung (MENOX EL2000, Kuraray Co.Japan) was performed between RV outlet and LA for ten of the RVF model. As we lost one animal during operation, nine (4.8-8.4kg, mean 6.5kg) were used to evaluate the gas transfer and cardiac function. All the cases showed the m-RVP (average 20.7(]SY.+-。[)4.2mmHg) after the RV-LA hypass was equal to the preoperative value or dropped, and the average cardiac function tended to be improved. Experiment III.After experiment II,the nine dogs were performed ligation of mPA and total RV-LA bypass was started. Five (4.8-8.4kg, mean 6.6kg) of nine RVF model were supported over 6 hours and evaluated the gas transfer and cardiac function (group I), while the other four died soon after ligation of mPA due to RVF.Five non-PA banding mongrels with the membrane oxygenator were used as control (Group II). Group I,as well as Group II,showed good gas transfer rates, averages of 32.5 (]SY.+-。[) 8.3ml/min.of 02 and 37.2 (]SY.+-。[) 11.6ml/min.of CO2 with a blood flow rate of 0.68 (]SY.+-。[) 0.19 L/min..
A partial bypass between RV-LA with the commercially available membrane oxygenator provides better recovary of RVF than a total bypass in RVF model.
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