| Project/Area Number |
07671480
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Nagasaki University |
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Principal Investigator |
TAKAGI Masatake Nagasaki University, School of Medicine, Assistant, Professor, 医学部, 助教授 (30136642)
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| Co-Investigator(Kenkyū-buntansha) |
HASHIYADA Hiroshi Nagasaki University, School of Medicine Hospital, Assistant, 医学部・附属病院, 助手 (50284691)
MIYAGAWA Naotake Nagsaki Universitiy, School of Medicine Hospital, Lecture, 医学部・附属病院, 講師 (10136666)
KUGIMIYA Toshiyasu Nagasaki University, School of Medicine, Professor, 医学部, 教授 (30039820)
柴田 隆一郎 長崎大学, 医学部, 助手 (60226181)
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| Project Period (FY) |
1995 – 1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1996: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1995: ¥1,100,000 (Direct Cost: ¥1,100,000)
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| Keywords | ACUTE ARTERIAL OCCLUSION / MYOGLOBINEMIA / ACUTE RENAL FAILURE / alpha-fetoprotein / ミオグロビン / 腎機能傷害 / 多臓器不全 / 血中乳酸値 / 腎機能障害 |
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| Research Abstract |
Thirty four patients with abdominal aortic aneurysm, who underwent graft replacement at Nagasaki University Hospital between 1995 and 1997, were enrolled in this study.
Changes of blood mioglobin (Mb), lactic acid (Lc) and superoxide desmutase (SOD) were measured before and after aortic cross-clamping. Mb showed significant increase after cross-clamping. However, no correlation was found between clamping time and the blood levels of the above substances. Five of 34 patients showed abnormal myoglobinemia after crossclamping. Further study is necessary for clarifying mechnisms of these phenomenon.
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