| Project/Area Number |
07671482
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Kagoshima University |
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Principal Investigator |
MORIYAMA Yukinori Kagoshima University, University Hospital. Assistant Professor, 医学部・附属病院, 講師 (80221638)
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| Co-Investigator(Kenkyū-buntansha) |
IGURO Yoshihumi Kagoshima University, University Hosptial. Research Associate, 医学部・附属病院, 助手 (20222854)
MASUDA Hiroshi Kagoshima University, University Hospital. Research Associate, 医学部・附属病院, 助手 (10253866)
岩村 弘志 国立南九州中央病院, 医長 (20244238)
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| Project Period (FY) |
1995 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1997: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1996: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1995: ¥700,000 (Direct Cost: ¥700,000)
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| Keywords | Hypothermia / Postcardiotomy ventricular failure / IABP / Oxygen consumption / 重症心不全 / 表面冷却 / 開心術 / 術後心不全 / 低体温 |
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| Research Abstract |
Surface-cooling hypothermia was applied in 9 patients together with intraaortic balloon pump (IABP) support for postcardiotomy ventricular failure. They consisted of 3 coronary artery bypass graftings (CABGs), 2 aortic valve replacement (AVRs), 1 repair for left ventricular rupture after mitral valve replacement (MVR), 1 MVR+CABG,1 MVR+AVR+tricuspid valve annuloplasty, and 1 Hemiarch repair. The criteria for induction of hypothermia was less than 2.0 L/min/m^2 of cardiac index with greater than 18mmHg of pulmonary capillary wedge pressure under IABP and maximum pharmacologic support. Blood temperature was maintained at around 33ﾟC to keep mixed venous oxygen saturation up to 50%. After induction of hypothermia, the tissue oxygen consumption decreased significantly with no hemodynamic deterioration. All nine patients finally discontinued IABP support and six of them were ultimately discharged from the hospital. We believe that the use of hypothermia with IABP support become one of the therapeutic options in selected cases of postoperative cardiac failure.
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