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The effect of body temperature in the acute phase of subarachnoid hemorrhage on the long term outcome

Research Project

Project/Area Number 07671544
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionTeikyo Univ.School of Med.

Principal Investigator

TAKAGI Kiyoshi  Teikyo Univ.School of Med., Dept.of Neurosurgery, Assistant Prof., 医学部, 講師 (40197059)

Co-Investigator(Kenkyū-buntansha) NAKAYAMA Hitoshi  Teikyo Univ.School of Med., Dept.of Neurosurgery, Asociate Prof., 医学部, 助教授 (00147050)
OKA Hidemune  Teikyo Univ.School of Med., Dept.of Neurosurgery, Asociate Prof., 医学部, 助教授 (20010382)
TAMURA Akira  Teikyo Univ.School of Med., Dept.of Neurosurgery, Professor, 医学部, 教授 (80111532)
Project Period (FY) 1995 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥200,000 (Direct Cost: ¥200,000)
Fiscal Year 1996: ¥200,000 (Direct Cost: ¥200,000)
Keywordscerecrovascular disease / subarachnoid hemorrhage / temperature / hypothermia / outcome / subarachnoid hemmorrhage / クモ膜下出血 / 体温 / 予後 / retrospectively study / WFNS分類
Research Abstract

Background : In recent years, it has been disclosed experimentally and clinically that the brain temperature is one of the most important factors that decide the outcome of the brain disease. The purpose of this study is to evaluate the effect of the body temperature control in the acute phase of the subarachnoid hemorrage.
Materials and Method : First, we developed a new SAH grading scale based solely upon the Glasgow Coma Scale and the standard outcome evaluated by Glasgow Outcome Scale with numerical translation (dead=1 to good recovery=5) for each grade. We investigated the relatioship between the SAH grade and the body temperature on the admission. Eight patients with SAH received temperature control therapy in the acute phase of the disease uwing cooling blanket to be kept at slightly hypothermic condition. The outcome was evaluated at 3 months after the onset.
Results : A newly developed SAH grading is as follows ; I (GCS=15), II (GCS=11-14), III (GCS=8-10), IV (GCS=4-7), and V (GCS=3). Standard outcomes for each SAH grade are as follows respectively ; 4.68(]SY.+-。[)0.05,4.10(]SY.+-。[)0.06,3.55(]SY.+-。[)0.11,2.65(]SY.+-。[)0.10, and 1.81(]SY.+-。[)0.22. The outcome of the patients with temperature control did not exceed the standard outcome. The body temperature in the patients with low SAH grade was significantly lower than those with high SAH grade.
Conclusion : These results suggest that the application of the hypothermia therapy to the patients with SAH must be done with great care in order to exceed the standard outcome.

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • Research Products

    (8 results)

All Other

All Publications (8 results)

  • [Publications] Gotoh O: "Glasgow Coma Scale in the Prediction of Outcome after Early Aneurysm Surgery" Neurosurgery. 39. 19-25 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Akira Tamura: "Clinical Pharmacology of Cerebral Ischemia" Ter Horst GJ and Korf J(eds).The Humana Press Inc., (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 高木 清: "脳血管攣縮 Vol.12" 太田富雄、浅野孝雄 他 中外医学社(in press),

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Gotoh O,Tamura A,Yasui N,Suzuki A,Hadeishi H,Sano K: "Glasgow coma scale in the prediction of outcome after early aneurysm surgery" Neurosurgery. 39. 19-25 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Akira Tamura, Kiyoshi Takagi, Kensuke Kawai: "Animal models used in cerebral ischemia and stroke research. Ter Horst GJ and Korf J (eds) Clinical pharmacology of cerebral ischemia." 265-294 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Gotoh O: "Glasgow Coma Scule in the Prediction of Outcome after Eary Aneurysm Surgery" Neurosurgery. 39. 19-25 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Akira Tamura: "Clinical Pharmacology of Cerebral Ischemia" Ter Horst GJ and Korf J (eds) The Humara Press Inc, (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 高木清: "脳血管攣縮 vol 12" 太田富雄、浅野孝雄 他 中外医学社(in press),

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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