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Hemodynamic Depression and Microthrombosis Formation in the Peripheral Areas of Cerebral Contusion

Research Project

Project/Area Number 07671547
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionNihon University

Principal Investigator

YAMAMOTO Takamitsu  Nihon Univ.Dep.of Neurological Surgery Assistant Professor, 医学部, 講師 (50158284)

Co-Investigator(Kenkyū-buntansha) TSUBOKAWA Takashi  Nihon Univ.Science Research Center Professor, 総合科学研究所, 教授 (80058958)
KATAYAMA Yoichi  Nihon Univ.Dep.of Neurological Surgery Professor, 医学部, 教授 (00125048)
Project Period (FY) 1995 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1997: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1996: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1995: ¥800,000 (Direct Cost: ¥800,000)
Keywordstrauma / brain injury / cerebral contusion / cerebral blood flow / microthrombosis / brain edema / tissue osmolality / rat / 血管内凝固 / 血小板
Research Abstract

Cerebral contusious sometimes cause progressive or delayd deterioration of neurological symptoms, which may result from secondary injury processes of the traumatized brain. It is important to elucidate pathophysiology underlying secondary brain damages, since one principal goal of treatments for traumatic brain injury is to prevent such secondary damages following the injury. In the present syudy, in order to elucidate the mechanisms of contusion-induced secondary cell injury processes, we investigated hemodynamic changes in cerebral contusion, and effects of anti-thrombosis and anti-coagulate drugs were tested in a rat cortical contusion induced by a controlled cortical impact device. Results (1)Histological examinations revealed that the initial histopathological finding in the peripheral area of contusion was microthrombosis formation, followed by brain edema and necrosis formation. These changes progressively extended to peripheral area surrounding the contusion. (2)In the central … More area of contusion, cerebral blood flow (CBF) was decreased to the ischemic level within 5-15 min after the injury induction. In the peripheral area, CBF was decreased to 20% of the beseline, returned to 40-60% level, and then decreased again to the ischemic level without any recovery. (3)A inhibitor of platelet activating factor (PAF), etizolam, attenuated the contusional necrosis formation as well as decreasing CBF in the peripheral but not in the central area of contusion. (4)The tissue osmolality of contusion increased immediately following the injury, and the tissue water content increased thereafter. (5)The concentration of the tissue cations (total amount of [Na^+]+[K^+] in the contusion did not show any significant changes, indicating inorganic ions do not mainly participate in the tissue osmolality increase. Discussion The results of the present study indicate that the microthrombosis formation in the peripheral areas of contusion may contribute to the secondary cell injury processes in cerebral contusion. Anti-thrombosis with a PAF antagonist has a therapeutic potential to attenuate the lschemic btain damage and subsequent edema formation following the contusion. The progressive increase in tissue osmolality is another cause of contusion-induced edema formation. Increases in metabolic intermediate osmoles and/or idiogenic osmoles resulting from the catabolic degradation of intracellular high molecular substances, e.g.phospholipids in cell membrane, may play a major role for the formation of osmotic potential and a resultant brain edema in the cerebral contusion. Less

Report

(4 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • 1995 Annual Research Report
  • Research Products

    (35 results)

All Other

All Publications (35 results)

  • [Publications] 山本 隆充、片山 容一、他: "骨傷のない頚椎損傷急性期の治療法:Killed end corticospinal evoked potentialの推移からみた治療法の検討" 日本パラプレジア医学会雑誌. 9(1). 24-25 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 山本 隆充、片山 容一、他: "大脳皮質運動領の直接刺激法と経頭蓋電気刺激法によって記録されるMEPの比較:同一症例における術中モニタリングの結果から" 脊髄電気診断学. 18(1). 143-146 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yamamoto T, Katayama Y, etc: "A study of methods of evaluating prolonged consciousness disturbance : Based on the results of deep brain stimulation therapy and long-term follow-up" The Society For Treatment of Coma. Vol.5. 99-102 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Aoyama N, Katayama, Y et al.: "Microthrombosis formation in cerebral contusion : A cause of trauma-induced secondary tissue damage" Advances in Neurotrauma Rescarch. Vol.7. 85-90 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Mori T, Katayama Y, Yamamoto T, et al.: "Progressive edema fomation in contused brain : Role of tissue osmolality and ion concentrations" Advances in Neurotrauma Research. vol.8. 15-17 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 山本 隆充、片山 容一: "遷延性意識障害の治療" 救急医学. 21. 1737-1742 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 山本 隆充: "最新脳神経外科学 手術中のモニター法" 1880(1137-1144) (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yamamoto T,Hirayama T,Katayama, Tsubokawa T,et al.: "Significance of neurological evaluation of the vegetative state" The society for treatment of coma. 4. 247-251 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yamamoto T,Fukaya C,Katayama Y,et al.: "A study of methods of evaluating prolonged consciousness disturbance : Based on the results of deep brain stimulation therapy and long-term follow-up" The Society For Treatment of Coma. 5. 99-102 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yamamoto T,Katayama Y,Maejima S,et al.: "5-HT3 antagonist for the treatment of central pain : comparison with the results of pharmacological tests" Pain Research. 12. 109-114 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yamamoto T,Katayama Y,Tsubokawa T,et al.: "Pharmacological classification of central post-stroke pain : comparison with the results of chronic motor cortex stimulation therapy" Pain. 72. 5-12 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Aoyama N,Katayama Y,Tsubokawa T,et al.: "Microthrombosis formation in cerebral contusion : A cause of trauma-induced secondary tissue damage." Advances in Neurotrauma Research. 7. 85-90 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Katayama Y,Koshinaga M,Tsubokawa T,et al.: "Role of excitatory amino acid-mediated ionic fluxes in traumatic brain injury." Brain Pathology. 5. 427-435 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Koshinaga M,Suma K,Maeda T,Katayama Y: "The role of traumatic depolarization and cytokine release in glial responses following traumatic brain injury." Neurotraumatology. 19. 167-172 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kurihara J,Yamamoto T,Katayama Y,et al.: "Experimental spinal cord injury induced by a controlled impact device : Electrophysiological and histological investigations" Advances in Neurotrauma Research. 8. 61-64 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Maeda T,Aoyama N,Katayama Y,et al.: "Selective neuronal cell death in the hippocampus following cortical contusion : role of EAA and programd cell death." Brain Hypoxia. 10. 79-81 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Maeda T,Kawamata T,Katayama Y: "Effect of hypothermia on hippocampal cell damages in the rat cortical impact contusion model." Neurotraumatology. 19. 162-166 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Mori T,Katayama Y,Yamamoto T,et al.: "Progressive edema formation in contused brain : Role of tissue osmolality and ion concentrations" Advances in Neurotrauma Research. 8. 15-18 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Suma T,Maeda T,Kano T,Katayama Y,et al.: "Temporal pattern of microglial response in adult rat hippocampus following direct infusion of granulocyte-macrophage colony stimulating factor." Advances in Neurotrauma Research. 7. 112-116 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kawamata T,Maeda T,Kano T,Katayama Y et al.: "Relative ischemic condition in traumatic brain injury." Neurotraumatology. 19. 128-132 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Katayama Y,Maeda T: Head Injury, Basic Research. In : Neurosurgical Review Vol.3('95). Miwashyoten, Tokyo, 153-165 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 山本隆充、片山容一、他: "骨傷のない頚椎損傷急性期の治療法:Killed end corticospinal evoked potentialの推移からみた治療法の検討" 日本パラブレジア医学会雑誌. 9(1). 24-25 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] 山本隆充、片山容一、他: "大脳皮質運動領の直接刺激法と経頭蓋電気刺激法によって記録されるMEPの比較:同一症例における術中モニタリングの結果から" 脊髄電気診断学. 18(1). 143-146 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Yamamoto T,Katayama Y,etc: "A study of methods of evaluating prologed consciousness disturbance:Based on the results of deep brain stimulation therapy and long-term follow-up" The Society For Treatment of Coma. Vol.5. 99-102 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Aoyama N,Katayama,Y et al.: "Microthrombosis formation in cerebral contusion : A cause of trauma-induced secondary tissue damage" Advanses in Neurotrauma Research. Vol.7. 85-90 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Mori T,Katayama Y,Yamamoto T,et al.: "Progressive edema formation in contused brain : Role of tissue osmolality and ion concentrations" Advabces in Neurotrauma Research. vol.8. 15-17 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 山本隆充、片山容一: "遅延性意識障害の治療" 救急医学. 21. 1737-1742 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 山本隆充: "最新脳神経外科学 手術中のモニター法" 1880(1137-1144) (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] 山本隆充、片山容一、他: "骨傷のない頚椎損傷急性期の治療法:Killed end corticospinal evoked potentialの推移からみた治療法の検討" 日本パラプレジア医学会雑誌. 9(1). 24-25 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 山本隆充、片山容一、他: "大脳皮質運動領の直接刺激法と経頭蓋電気刺激法によって記録されるMEPの比較:同一症例における術中モニタリングの結果から" 脊髄電気診断学. 18(1). 143-146 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Yamamoto T, Katayama Y, etc: "A study of methods of evaluating prolonged consciousness disturbance : Based on the results of deep brain stimulation therapy and long-term follow-up" The Society For Treatment of Coma. Vol.5. 99-102 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Aoyama N, Katayama,Y et al.: "Microthrombosis formation in cerebral contusion : A cause of trauma-induced secondary tissue damage" Advances in Neurotrauma Research. Vol.7. 85-90 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 山本隆充: "最新脳神経外科学 手術中のモニター法pp1137-1144" 朝倉書店(朝倉邦造)(編集者:坪川孝志、高倉、菊池), 1880 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Yoich Katayama, et al.: "Role of Excitatory Amino Acid-Mediated Ionic Fluxes in Traumatic Brain Injury" Brain Pathology. 5. 427-435 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Tatsuro Kawamata, et al.: "Tissue Osmotic Potential and Brain Edema in Cerebral Contusion" Advances in Neurotrauma Research. 6. 27-30 (1995)

    • Related Report
      1995 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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