| Project/Area Number |
07671607
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Orthopaedic surgery
|
|---|
| Research Institution | Dept of orthop. Fukushima Medical College |
|---|
Principal Investigator |
KIKUCHI Shinichi fukushima medical college Dept. of orthop. proffessor and chairman, 医学部, 教授 (80045773)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KONNO Shinichi fukushima medical college Dept. of orthop. Assistant professor, 医学部, 助手 (70254018)
|
|---|
| Project Period (FY) |
1995 – 1996
|
| Project Status |
Completed (Fiscal Year 1996)
|
| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1996: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1995: ¥900,000 (Direct Cost: ¥900,000)
|
|---|
| Keywords | Cauda equina / Nerve roots / Compression / Neurogenic claudication / Spinal stenosis |
|---|
| Research Abstract |
A new model for controlled, graded compression of the dog cauda equina was developed using the dog lumbar spine. The model was defined regarding macroscopic-, microscopic-, and vascular anatomy as well as regarding accuracy in pressure transmission.
The study was performed to develop a model for controlled, graded compession that would allow for acute, chronic and delayd compression.
Macroscopic examination, light microscopy and ink-injektion of the vasculature was used to assess the anatomic characteristics of the nerve tissue and the vasculature of the cauda equina in the dog lower lumbar spine. The relation between known pressures in the compression balloon used to compress the cauda equina and the pressure in the central thecal sac was assessed by me asuring the pressure in an artificial thecal sac with a pressure transducer.
The neural and vascular anatomy was found to have a close resemblance to the human cauda equina. The pressure in the thecal sac was within 5% of the pressure in the compression balloon at various pressure between 0-200 mm Hg. The presented model provides a good pressure transmission to the dog cauda equina which have an anatomy that closely resembles tha human cauda equina. The model may thus be well suited for physiologic studies of cauda equina compression. A double-balloon system may provide unique opportunities to induce both chronic compression and delayd compression, i. e. additional compression after a certain time of chronic compression to resemble the changes in pressure which are characteristic for neurogenic claudication.
|
