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Apoptosis in ischemia and reperfusion injury of limb.

Research Project

Project/Area Number 07671634
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionFUKUOKA UNIVERSITY

Principal Investigator

OHJIMI Hiroyuki  Fukuoka Univ.Hospital, Associate Professor., 助教授 (60160488)

Project Period (FY) 1995 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1996: ¥500,000 (Direct Cost: ¥500,000)
Keywordsapoptosis / limb / ischemia / reperfusion injury / 再灌流障害 / Apotosis / No reflow phenomenon / 虚血再潅流障害 / 四肢
Research Abstract

The mechanisms of cell death have been subject to debate. We studied whether an apoptotic type of cell death occurs in skin after ischemia and reperfusion injury.
METHODS AND RESULTS : We studied skin samples of rabbit lower limb that underwent ischemic condition achieved by 8 hours followed by 180 minutes of reperfusion. Extensive formation of DNA strand breaks, the typical biochemical feature of apoptosis was detected with the use of the in situ DNA end-labeling method. Apoptotic cells were observed particularly in the border zones of histologically necrotic skin, whereas very few apoptotic cells were present in the remote no necrotic skin.
CONCLUSIONS : This study provides evidence that in addition to overt necrosis, a subset of skin undergo apoptosis during ischemia-reperfusion injury. Apoptosis may provide a new target for skin slough during evolving ischemia and repurfusion injury in humans.

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] Ohjimi, H, Ogata, K., and Ojimi, T.: "A New method for the relief of adult phimosts." J.Urol.153. 1607-1609 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ohjimi, H., Ogata, K..: "An Elastic plastic splint to compress the ear after reconstriction using a temper a perotal fascial temp" Arm.Plast.Surg. 36(6). 652-654 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ohjimi, H., Ogata, K., Setsu, Y: "Modification of the gluteum maximams V-Yadvancement flap for casralulas" Plast.Resnstr.Surg.98(7). 1247-1252 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ohjimi, H., Ogata, K., Ohjimi, T: "A New method for the relief of adult phimosis." J.Urol. 153. 1607-1609 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ohjimi, H., Ogata, K: "An Elastic plastic splint to compress the ear after teconstruction using a temporoparietal fascial flap." Ann.Plast.Surg. 36 (6). 652-654 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Nagasaka, S., Fukushima, T., Goto, K., Ohjimi, H., Iwabuchi, S., Maehara, F: "Treatment of scalp arteriovenous malformation." Neurosurgery. 38 (4). 671-677 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ohjimi, H., Ogata, K., Setsu, Y., Haraga, I: "Modification of gluteus maximus V-Y advancement flap for sacral ulcers : The gluteal fasciocutaneous flap method." Plast.Reconstr.Surg. 98 (7). 1247-1252 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ohjimi,H.et al.: "Modification of the glutius maximus V-Y advencmet flak for secrd ulcers The glnbal tasciocutareans flap ncdrod" Plastic and Recsnstructive Surge. 98・7. 1247-1252 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Ohjimi,H.,Ogata,K.: "An Elactic pkctic splint to compress the earaflir liconstruction using a temporoparietal foscial flap" Amcls of Plastic Sungeny. 36・6. 652-654 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Nagastuka,S.,et al.: "Treatment of scelp artiriovenous meltocmaton" Neurosurgery. 38・4. 671-677 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 大慈弥裕之: "OS NOW(新時代の整形外科治療)No.26足部疾患の治療・合趾症" (株)メジカルビュー社(発表予定), (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] K. Kushiku, H. Ohjimi, Y. Yamada et al: "Activetion of Endogenons Thranboxane A_2 Biosynthesis Mesiatis Prestmrtic Inhibition by Endothulin of Dog steuat Gaglinic Tow." The Jaurnal of Pharmadokogy and Experimented Theapentics. 272. 70-76 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] H. Ohjimi et al: "A New Method of the Rilief of Adult Phimosis" The Journal of Orology. 153. 1607-1609 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] H. Ohjimi et al: "Modification of the Gluten Maxims V-Yadvanunout Flap" Plastic and Reconstructive Surgery. 1996(Accepted).

    • Related Report
      1995 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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