| Project/Area Number |
07671650
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Hamamatsu University School of medicine |
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Principal Investigator |
MORITA Koji Hamamatsu University School of Medicine, Hospital of Hamamatsu University, Research Associate, 医学部附属病院, 助手 (30115513)
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| Co-Investigator(Kenkyū-buntansha) |
DOI Matsuyuki Hamamatsu University School of Medicine, Hospital of Hamamatsu University, Lectu, 医学部附属病院, 講師 (10155616)
IKEDA Takehiko Hamamatsu University School of Medicine, Research Associate, 医学部, 助手 (10262817)
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| Project Period (FY) |
1995 – 1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 1996: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1995: ¥2,100,000 (Direct Cost: ¥2,100,000)
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| Keywords | muscle sympathetic nerve activity / microneurography / stellate ganglion block / tibial nerve / continuos negative pressure breathing / continuos positive pressure breathing / 交感神経活動度 / レーザドップラ血流計測 / 積分値評価法 / タングステン電極 |
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| Research Abstract |
We have developed the system which could measure muscle sympathetic nerve activity (MSNA) and could quantify the activity level of them. The system used the electro-magnetic shielding and isolated differential preamplifiers for discriminating electrical burst potential in the nerve from the environmental noise in surgical rooms or in the intensive care rooms. By using this quantitative measurement system, we have found the clinical findings : 1) Effects of stellate ganglion block on tibial nerve muscle sympathetic activity. 2) Effects of positive and negative pressure breathing on muscle sympathetic nerve activity. Stellate ganglion block increases heart rate and systemic blood pressure, and the reason is estimated as the block of afferent flux of vagal nerve activity from the baroreceptor on the aortic arch. We have found that the left stellate ganglion block increased efferent MSNA on tibial nerve because of the efferent muscle sympathetic nerve activity (MSNA) is affected by the baroreceptor response. Increasing levels of continuous positive pressure breathing (CPPB) at 5,10, and 15 mmHg produced increasing levels of MSNA,however, during continuos negative pressure breathing (CNPB), MSNA was virtually constant. Mean blood pressure decreased and heart rate increased during CNPB,while neither factor changed significantly during CPPB.CVP increased during CPPB and decreased during CNPB.These results suggest that CPPB and CNPB do not have the inverse effects on MSNA.
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