• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The inhibition of L-selectin, a leukocyte rolling receptor, attenuates neutrophil accumulation in inflammatory sites.

Research Project

Project/Area Number 07671657
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionOsaka University

Principal Investigator

TAENAKA Nobuyuki  Osaka University Hospital, Assistant Professor, 医学部・付属病院, 講師 (10127243)

Co-Investigator(Kenkyū-buntansha) FUJINO Yuji  Osaka University Hospital, Assistant, 医学部・付属病院, 助手 (50252672)
NISHIMURA Shinya  Osaka University Hospital, Assistant, 医学部・付属病院, 助手 (00263286)
Project Period (FY) 1995 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1996: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1995: ¥1,200,000 (Direct Cost: ¥1,200,000)
Keywordsadhesion molecule / neutrophil / lung inflammation / 肺障害 / L-セレクチン
Research Abstract

The polysaccharide fucoidin, a homopolymer of sufated L-fucose, is known, by interfering with the function of L-selection, to inhibit leukocyte rolling, which is an early and essential step in the process of leukocyte extravasation into inflamed sites. We tested the inhibitory effect of fucoidin on neutrophil accumulation in lung inflammation iduced by phorbol myristate acetate and peritoneal inflammation iduced by thioglycollate in rabbits. Pretreatment (10 mg/kg) followed by continuous administration (10 mg/kg/h) of fucoidin dramatically reduced the number of neutrophils recruited into the lungs (determined by neutrophil counts in bronchoalveolar lavage fluid ; 97.7(]SY.+-。[)0.52% reduction) and peritoneal cavity (determined by neutrophil counts in peritoneal lavage fluid ; 98.4(]SY.+-。[)1.29% reduction). Fucoidin treatment also increased the systemic neutrophil count. These results suggest that the inhibition of leukocyte rolling, which may be a primary function of fucoidin, leads to a reduction of neutrophil accumulation at inflammatry sites, which may be beneficial for attenuating neutrophil-mediated tissue injury.

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • Research Products

    (4 results)

All Other

All Publications (4 results)

  • [Publications] Shimaoka M: "Fucoidin,a potent inhibitor of leukocyte rolling,prevents neutrophil influx into phorbol-ester-induced inflammatory sites in rabbit lungs." Am J Respir Crit care Med. 153. 307-311 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Shimaoka M,Ikeda M,IIda T,Taenaka N,Yoshiya I,Honda T: "Fucoidin, a potent inhibitor of leukocyte rolling, prevents neutrophil influx into phorbol-ester-induced inflammatory sites in rabbit lungs." Am J Respir Crit Care Med. 153. 307-311 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Motomu Shimaoka: "Fucoidin,a potent inhibitor of leukocyte rolling,prevents neutrophil influx into phorbol-ester-induced inflammatory sites in rabbit lungs" American Journal of Respiratay and Critical Care Medicine. 153. 307-311 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Motomu Shimaoka: "Fucoidin,a potent inhibitor of leukocyte. rolling,prevents neutrophil influx into phorbol-ester-induced inflammatory sites in rabbit lungs." American Journal of Respiratory and Critical Care Medicine. 153. 307-311 (1996)

    • Related Report
      1995 Annual Research Report

URL: 

Published: 1995-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi