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THE EFFETS OF LIDOCAINE ON ENDOTOXIN-INDUCED MULTIPLE ORGAN FAILURE.

Research Project

Project/Area Number 07671660
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionKOBE UNIVERSITY SCHOOL OF MEDICINE

Principal Investigator

MAEKAWA Nobuhiro  KOBE UNIVERSITY SCHOOL OF MEDICINE,DEPARTMENT OF ANESTHESIOLOGY,ASSOCIATE PROFESSOR, 医学部, 助教授 (30127394)

Co-Investigator(Kenkyū-buntansha) MIKAWA Katsuya  KOBE UNIVERSITY SCHOOL OF MEDICINE,DEPARTMENT OF INTENSIVE CARE MEDICINE,ASSISTA, 医学部附属病院, 講師 (40229662)
Project Period (FY) 1995 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1996: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 1995: ¥1,000,000 (Direct Cost: ¥1,000,000)
KeywordsENDOTOXIN / MULTIPLE ORGAN DYSFUNCTION SYNDROME / LOCAL ANESTHETICS / ARDS / NEUTROPHIL / 肝不全 / 心不全 / 好中球 / 活性酸素 / サイトカイン / 一酸化窒素
Research Abstract

We conducted the current study to assss the effects of lidocaine on endotoxin-induced multiple organ failure (MOF). Seventeen male Japanese white rabbits were divided into two groups : Group S (control, n=8) received iv endotoxin (E.Coli) and saline and Group L (n=9) did endotoxin and lidocaine infusion. Arterial blood samples for measurement of PaO2, GOT,GPT,BUN,and creatinine were drawn 0 hr, 6 hr, 12 hr, and 24 hr after endotoxin. Lung mechanics were measured by the passive expiratory flow-volume technique before endotoxin and 24 hr after endotoxin. The animals were killed 24 hr after endotoxin. Then, the lung, kidney, and liver were removed to determine wet to dry weight ratios (W/D) and myeloperoxidase activities. Cytokine and albumin concentrations in bronchoalveolar lavage (BAL) fluid were measured. The lung, kidney, and liver were also fixed by 4% glutaraldehyde solution. The specimens were stained with hematoxylin and eosin and examined under a light microscope. Endotoxin decreased PaO_2 and lung compliance. Lindocaine successfully attenuated deterioration of oxygenation and compliance. Endotoxin also increased the W/D weight ratio of the three organs, and albumin and interleukin (IL) -6, IL-8 in BAL fluid. Lidocaine attenuated the increases. The myeloperoxidase activities of the lung, kidney, and liver were greater in rabbits which did not receive lidocaine. Endotoxin caused extensive morphologic organ damages, which were lessened by lidocaine treatment. These results indicate that lidocaine pre-treatment attenuates endotoxin-induced MOF in rabbits. Because lidocaine markedly reduced the myeloperoxidase of the organs prepared from rabbits with endotoxin, the drug may attenuate the MOF in part by inhibiting activation of neutrophils.

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • Research Products

    (18 results)

All Other

All Publications (18 results)

  • [Publications] Mikawa K, et al.: "Attenuation of hyperoxic lurg injury in rabbits with SOD." Acta Anaesthesiol Scand. 39. 317-322 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Nishina K, et al.: "Does early post-treatunent with lidocorhe attenuate evdotoxin induced lung ingury" Anesthesiology. 83. 169-177 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Takao Y, et al.: "Lidocaine attenuates hyperoxic lung injury in rabbits" Acta Anaesthesiol Scand. 40. 318-325 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Nishina K, et al.: "Inhaled nitric oxide does not prevent endotoxin-indueed lung injury" Acta Anaesthesiol Scand. 41(in press). (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 三川,仁科,尾原 他: "NO研究の基礎と臨床 vol.1" 医学図書出版, (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 三川,仁科,志賀,他: "NO研究の基礎と臨床 vol.2" 医学図書出版, (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Mikawa K,Nishina K,Maekawa N,Obara H.: "Attenuation of hyperoxic lung injury in rabbit with superoxide dismutase : effects on inflammatory mediators" Acta Anaesthesiol Scand. 39. 317-322 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Nishina K,Mikawa K,Maekawa N,Takao Y,Obara H.: "Does early post-treatment with lidocaine attenuate endotoxin-induced acute lung injury in rabbits?" Anesthesiology. 83. 169-177 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Takao Y,Mikawa K,Nishina K,Maekawa N,Obara H.: "Lidocaine attenuates hyperoxic lung injury in rabbits." Acta Anaesthesiol Scand. 40. 318-325 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Nishina K,Mikawa K,Takao Y,Obara H.: "Inhaled nitric oxide does not prevent endotoxin-induced lung injury in rabbits." Acta Anaesthesiol Scand. 41[in press]. (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Mikawa K,Nishina K,Maekawa N,Obara H.: Aalysis of NO Inhalation in Adults. In : Shinozaki M,Marukawa S,eds. Basic and Clinical Study of NO,vol.1.Igakutosho-shuppan, Tokyo, 30-34 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Mikawa K,Nishina K,Shiga M,Maekawa N,Obara H.: Study of Exhaled No.In : NO Research Meeting Group, ed. Basic and Clinical Study of NO,vol.2.Igakutosho-shuppan, Tokyo, 45-48 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Takao Y,Mikawa K,et al.: "Lidocaine attenuates hyperoxic lung injury" Acta Anaesthesiol Scand. 40. 318-325 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Nishina K,Mikawa K,et al.: "Inhaled nitric oxide does not prevent endotoxin-induced lung injury" Acta Anaesthesiol Scand. 41 (in press). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] 三川.仁科.他: "NO研究の基礎と臨床VOL.2" 医学図書出版, 79 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Nishina k, et al.: "Does early post-treatment with lidocaine attenuate ALI in Rabbits." Anesthesiology. 83. 167-177 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Takao Y, et al.: "Lidocaine attenuates hyperoxic lung injury in rabbits" Acta Anaesthesidologica Scandinavica. 40(in press). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] 前川 信博: "呼吸管理の基礎知識" JCHNS. 11. 1711-1717 (1995)

    • Related Report
      1995 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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