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THE RELATIONSHIP OF TACHYPHYLAXIS IN EPIDURAL ANESTHESIA AND CSF pH CHANGE

Research Project

Project/Area Number 07671673
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionMiyazaki Medical College

Principal Investigator

KATSUKI Hiroshi  Miyazaki Medical College, Department of Anesthesiology, Instructor, 医学部, 助手 (80194786)

Co-Investigator(Kenkyū-buntansha) TAKASAKI Mayumi  Miyazaki Medical College, Department of Anesthesiology, Professor, 医学部, 教授 (30094212)
Project Period (FY) 1995 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1996: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1995: ¥1,600,000 (Direct Cost: ¥1,600,000)
Keywordsepidural anesthesia / tachyphylaxis / csf pH
Research Abstract

This study was carried out to elucidate the mechanism of tachyphylaxis in clinical epidural anesthesia. The hypothesis was that repetitive administration of large dose local anesthetics may increase csf pH will cause failure in csf pH regulation, result in csf pH increase, which prevent transdural influx of unionized forms of local anesthetic molecule. Then abrupt tachyphylaxis may take place.
Although, we demonstrated that extracellular procaine perfusion resulted in pHi increase in crayfish giant axon with only 1-4 mM,epidurally administered 2-5% procaine solution did not affect csf pH in rat. And, because of difficulty in settlement of epidural catheter in rat epidural space, we could not achieve stable epidural anesthesia in rats, so no evidence of tachypylaxis was observed in rats.
As to the fact that no effect of epidural procaine on csf pH,we considered that the rat csf volume is too large to be affected by epidurally administered small dose of procaine, or transdural procaine influx is not so large as we expected.

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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