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STUDY ON THE CHANGE OF INTRACARDIAC CONDUCTION SYSTEM AND ITS MECHANISM DURING EPIDURAL ANALGESIA

Research Project

Project/Area Number 07671679
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionOSKA CITY UNIVERSITY

Principal Investigator

NISHIKAWA Kiyonobu  OSAKA CITY UNIVERSITY,MEDICAL SCHOOL,ASSICIATE PROFESSOR, 医学部, 助教授 (20145791)

Co-Investigator(Kenkyū-buntansha) YUKIOKA Hidekazu  OSAKA CITY UNIVERSITY,MEDICAL SCHOOL,ASSOCIATE PROFESSOR, 医学部, 助教授 (80117986)
Project Period (FY) 1995 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1997: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1996: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1995: ¥900,000 (Direct Cost: ¥900,000)
KeywordsEPIDURAL OPIOIDS / ALPHA2-AGONISTS / CARDIAC SYMPATHETIC NERVE ACTIVITY / INTRACARDIAC CONDUCTION / α_2・アゴニスト / プロポフォール
Research Abstract

The effects of epidural analgesia with opioids and clonidine, one of the alpha-2 agonists, during general anesthesia on cardiac and renal sympathetic nerve activity and intracardiac conduction were studied in the cats. Thoracic epidural administration of morphine during alpha-chloralose anesthesia dramatically decreased sympathetic nerve activity and attenuated sinus nodal and AV nodal functions. Alomost the same effects were observed with epidural morphine in the cat baroreceptor nerves and vagal nerves were sectioned. Lumbar epidural administration of morphine has shown the same effect as thoracic epidural administration, so epidural morphine was supposed to spread extensively in CSF and act not only on spinal cord but also brainstem. This was probably due to the hydrophilic property of morphine. Epidural fentanyl or meperidine also depressed sympathetic nerve activity and intracardiac conduction, however showed a segmental depression of sympathetic activity. These depressions with meperidine were only partially reversed with intravenous naloxon.
Epidural clonidine, one of the alpha-2 agonists, also showed decrease in sympathetic nerve activity and attenuation of sinus nodal and AV nodal functions. The dose effect of epidural clonidine was not linear, which was maximal at 4 microgram/kg.

Report

(4 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • 1995 Annual Research Report
  • Research Products

    (13 results)

All Other

All Publications (13 results)

  • [Publications] Kiyonobu Nishikawa, Mitsuhide Yabe, Takekazu Terai, Hidekazu Yukioka, Mitsugu Fujimori: "The effects of dobutamine and phenilephsine an atrieventrieular conduction during combined use of halothane and thoracic epidural lidocaine" Anesthesia and Analgesia. 82(3). 551-557 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Mitsuhide Yabe, Kiyonobu Nishikawa, Takekazu Terai, Hidekazu Yukioka, Mitsugu Fujimori: "The effects of intrinsic nitric oxide on cardiac newal regulation in cats" Anesthesia and Analgesia. 86(6). 1194-1200 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Takashi Mori, Kiyonobu Nishikawa, Takekazu Terai, Hidekazu Yukioka, Akira Asada: "The effects of epidaral morphine on sympathetic nerve actibity and intracareiac conduction in α-chloralose anesthetized cats." Anesthesiology. 87(3A). A576 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Takashi Mori, Kiyonobu Nishikawa, Takekazu Terai, Hidekazu Yukioka, Akira Asada: "The effects of epidaral morphine on cardiac and renal nerve activity in α-chloralose-anesthetized cats." Anesthesiology. 88(6). 1558-65 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 森隆,西川精宣,浅田章: "硬膜外モルヒネ,フェンタニルの交感神経活動に及ぼす作用の検討" 第2回神経麻酔・集中治療研究会プロシーデイング. (印刷中). (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kiyonobu Nishikawa, Mitsuhide Yabe, Takashi Mori, Takekazu Terai, Hidekazu Yukioka, Mitsugu Fujimori: "The effects of dobutamine and phenylephrine on atrioventricular conduction during combined use of halothane and thoracic epidural lidocaine." Anesth Analg. 82(3). 551-557 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Mitsuhide Yabe, Kiyonobu Nishikawa, Takekazu Terai, Hidekazu Yukioka, Mitsugu Fujimori: "The effects of intrinsic nitric oxide on cardiac neural regulation in cats." Anesth Analg. 86(6). 1194-1200 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Takashi Mori, Kiyonobu Nishikawa, Takekazu Terai, Hidekazu Yukioka, Akira Asada: "The effects of epidural morphine on sympathetic nerve activity and intracardiac conduction in alpha-chloralose anesthetized cats." Anesthesiology. 87(3A). A576 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Takashi Mori, Kiyonobu Nishikawa, Takekazu Terai, Hidekazu Yukioka, Akira Asada: "The effects of epidural morphine on cardiac and renal sympathetic nerve activity in alpha-chloralose-anesthetized cats." Anesthesiology. 88(6). 1558-65 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Takashi Mori, Kiyonobu Nishikawa, Akira Asada: "Study on the effects of epidural morphine and fentanyl on sympathetic nerve activity." Proceedings of the 2nd neuroansethesia-intensive care meeting. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Takashi Mori,Kiyonobu Nishikawa,Takekazu Terai,Hidekazu Yukioka,Akira Asada: "The effects of opidural morphzne on cardiac and nenal sympathetic nerve activity in α-chloralose-anesthetized cats" Aneathesiology. (印刷中).

    • Related Report
      1997 Annual Research Report
  • [Publications] Kiyonobu Nishikawa, et al.: "The effects of dobutambre and phenylephrin on atrcoventriclar conduction during combined use of halothane and thoracle epidural lidncaine" Anesth Analg. 21. 551-557 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Osamu Morimoto, et, al.: "Effects of intravenous mapivanaim on renal sympathethe narve activity in the cat during nitrous oxide and nitrous oxide-harothane anesthesia" Reg Anesth. 21. 41-48 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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