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A Study about Effects of Anesthesia on Hepatic Circulation, Oxygen Metabolism, Intra-cellular Ca^<++> Mobilization and Liver Injury

Research Project

Project/Area Number 07671683
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionSaitama Medical School

Principal Investigator

MATSUMOTO Nobuyuki  Saitama Medical School, Faculty of Medicine, Associate Professor, 医学部, 助教授 (60095388)

Co-Investigator(Kenkyū-buntansha) MIYAZAKI Takashi  Saitama Medical School, Faculty of Medicine, Assistant, 医学部, 助手 (30265417)
Project Period (FY) 1995 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1996: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1995: ¥200,000 (Direct Cost: ¥200,000)
KeywordsAnesthetics / Hepatic blood flow / Hapatic oxygen metabolism / Nitric oxide (NO) / Ca^<++> ion / Constitutive nitric oxide synthase / Liver injury / NO assay / Anesthetics / Liver blood flow / Liver oxygen consumption / Nitric oxide (NO) / Ca++ion / constitutive Nitric oxide synthase / Liver injury / NO analysis / 麻酔 / 肝循環 / 細胞内カルシウム
Research Abstract

1) Effects of halothane, isoflurane and sevoflurane on hepatic blood flow (HBF), oxygen metabolism (HOM) and energy carge (HEC) were investigated in mongrel dogs during hypoxemia or hepatologectomy. Isoflurane and sevoflurane maintained HBF,HOM and HEC better than halothane. These results indicate that liver injury based on imbalance of HOM would not be induced by isoflurane or sevoflurane except under severe hypoxic condition. 2) HBF and HOM were also investigated in beagles during cardiopulmonary bypass (CPB) with fentanyl anesthesia. Increasing the dose of fentanyl to 50 mug/kg/h during CPB decreased HBF and suppressed HOM,while 10mug/kg/h of fentanyl produced minimal effects on HBF and HOM,so far as perfusion rate was within 80% of aortic blood flow of pre-CPB value. A large dose of fentanyl during CPB combined with hypoxemia could possibly cause liver injury. 3) Organ perfusion is regulated by contraction and relaxation of smooth muscles around vessels. In generally speaking, this regulation would be influenced by nitric oxide (NO) production and formation, and also same in hepatic sinusoids. In the liver, NO synthesized by constitutive NO synthase (cNOs) was assumed to control hepatic sinusoidal micro-circulation. CNOS requires Ca^<++> ion during synthesis of NO and so has tight correlation with intra-cellular free Ca^<++> concentration. We established a new highly sensitive method for measurement of chemical compounds which is related to cNOS-dependent NO in whole blood at steady state, and are investigating the relationship among NO production, intra-cellular Ca^<++> mobilization and decrease of HBF by anesthetics.

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • Research Products

    (17 results)

All Other

All Publications (17 results)

  • [Publications] 松本延幸 ほか: "麻酔と肝臓……麻酔が肝血流に及ぼす影響" Anesthesia Today. 5. 4-13 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 薗田勝,宮崎孝 ほか: "血球内一酸化窒素(NO)関連化合物の高感度測定に関する研究" 磁気共鳴と医学. 7. 188-191 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 薗田勝,宮崎孝 ほか: "全血中NO関連化合物の測定とその動態に関する研究" 磁気共鳴と医学. 8. 162-165 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Masaru Sonoda,Takashi Miyazaki et al: "An Assay Method for Nitric Oxide-Related Compound in Whole Blood" Analitical Biochemistry. 247(Accepted at Fed.1/1997). (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 松本延幸: "図説最新麻酔学シリーズ第3巻 麻酔中の患者の生理学 肝機能" メジカルビュー社, 262(うち105-115) (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Matsumoto, N.et al: "The effect of anesthesia on hepatic blood flow" Anesthesia Today. Vol.5, No.1. 4-13 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Sonoda, M.Miyazaki, T.et al: "A study on the highly sensitive measurements of the nitric-oxide related compounds in blood samples" Magnetic Resonance in Medicine. Vol.7. 188-191 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Sonoda, M.Miyazaki, T.et al: "Measurements of the nitric-oxide related compounds in whole blood and their metabolic fate" Magnetic Resonance in Medicine. Vol.8. 162-165 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Sonoda, M.Miyazaki, T.et al: "An assay method for nitric oxide-related compounds in whole blood" Analitical Biochemistry. Vol.247 (accepted at Feb.1). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Matsumoto, N.et al: Text Book of Anesthesiology-Fully Illustrated-Vol.1. Physiology during Anesthesia-Liver Function, 105-115 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 松本延幸 ほか: "麻酔と肝臓-麻酔が肝血流量に及ぼす影響" Anesthesia Today. 5. 4-13 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 薗田勝、宮崎孝 ほか: "血球内一酸化窒素(NO)関連化合物の高感度測定に関する研究" 磁気共鳴と医学. 7. 188-191 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 薗田勝、宮崎孝 ほか: "全血中NO^-関連化合物の測定とその動態に関する研究" 磁気共鳴と医学. 8. 162-165 (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Masaru Sonoda,Takashi Miyazaki etal: "An Assay Method for Nitric Oxide-Retated Compound in Whole Blood" Analitical Biochemistry. 247(Accepted at Feb.1/1997). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] 松本延幸 ほか: "図説最新麻酔学シリーズ第1巻3.麻酔中の患者の生理-肝機能-" メジカルビュー社, 262(105-115) (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 松本延幸ほか: "麻酔と肝臓-麻酔が肝血流量に及ぼす影響-" Anesthesia Today. 5(予定). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] 松本延幸ほか: "図説 最新麻酔学シリーズ 第1巻3麻酔中の患者の生理-肝機能-" メジカルビュー社(予定), (1996)

    • Related Report
      1995 Annual Research Report

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Published: 1995-04-01   Modified: 2019-12-23  

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