| Project/Area Number |
07671708
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Chiba University |
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Principal Investigator |
OKANO Tatsuya Chiba University Hospital, Urology, Lecturer, 医学部・附属病院, 講師 (00185456)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Junichiro Chiba University Hospital, Division of Blood Transfusion, Senior Resident, 医学部・附属病院, 医員
ISEKI Toru Chiba University, 1st Internal Medicine, Assistant, 医学部, 助手 (10232365)
ASAI Takayoshi Chiba University Hospital, Division of Blood Transfusion, Lecturer, 医学部・附属病院, 講師 (00134396)
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| Project Period (FY) |
1995 – 1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1996: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1995: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | testicular tumor / blood stem cell transplantation / high dose chemotherapy |
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| Research Abstract |
Between 1995 and 1996, a total of twenty-four harvests of peripheral blood stem cells (PBSCs) was performed on twelve patients with advanced germ cell tumors (non-seminoma 10, seminoma 2). To mobilize PBSCs, eleven patients underwent conventional chemotherapy (CDDP,etoposide, blecomycin) combined with granulocyte colony stimulating factor (G-CSF) and one patients were administered G-CSF alone. A mean yield of 6.2*10^8/kg for mononuclear cells and 14.4*10^6/kg for CD34 positive cells were obtained.
Then a total of two treatments of high dose chemotherapy and autologous peripheral blood stem cell transplantation (PBSCT) was performed on two patients with advanced germ cell tumors (non-seminoma). They were initial cases to whom the high dose chemotherapy was administered after 3 or 4 courses of conventional chemotherapy. The high dose regimen consisted of CDDP (120mg/m^2), etoposide (1800mg/^2) and cyclophosphamide (120mg/kg) or of carboplatin (1250mg/m^2), etoposide (1500mg/m^2) and ifosfamide (7.5g/m^2). The peripheral blood stem cell infusion was administered 3 days after the last dose of chemotherapy. These two patients achieved a partial remission after the high dose chemotherapy, and achieved a continuous complete remission after surgical removal of residual tumors. White blood cells recovered to greater than 1000/mm^3 9 days after PBSCT.Major toxicities were nausea, vomiting, diarrhea and mucositis. No cardiac toxicity or severe infection occurred.
These results suggest that early introduction of high dose chemotherapy is necessary to improve the prognosis of advanced germ cell tumors. And PBSCT appears to be useful for the bone marrow rescue.
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