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Electrically Induced Auditory Brainstem Response as a Clinical Tool in Explicating Sudden Deafness

Research Project

Project/Area Number 07671869
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionMiyazaki Medical College

Principal Investigator

USHISAKO Yasuaki  Miyazaki Medical College, Medical Science, Assistant, 医学部, 助手 (10185001)

Co-Investigator(Kenkyū-buntansha) TONO Tetsuya  Miyazaki Medical College, Medical Science, Assistant Professor, 医学部, 助教授 (80145424)
定永 正之  宮崎医科大学, 医学部, 助手 (70271137)
Project Period (FY) 1995 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1996: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1995: ¥1,000,000 (Direct Cost: ¥1,000,000)
KeywordsEABR / sudden deafness / Feosemide / stria vascularis / EP依存性難聴 / モルモット
Research Abstract

(1)Auditory brainstem responses to electrical stimulation (EABR) could be easily obtained by using bipolar electrodes in cochlear of guinea pig.
(2)EABR to 500muA electrical stimulation in normal guinea pig showed five different positive peaks, but EABR wave forms were much different in each other than ABR wave forms.
(3)Each peak latencies of EABR to 500muA were shortened about 1msec. compairing from its of ABR.
(4)The mean EABR threshhold in normal guinea pigs was 55muA,ranging from 20muA to 100muA.
(5)Cochlear damages caused by inserting electrodes for EABR recording introduced 8dB ascending in ABR threshhold.
(6)Any latencies and thresholds in our EABR recordings were not infruenced by administrating 100mg/kg Frosemide.
(7)Any latencies and thresholds in our EABR recordings were not infruenced by administrating 40mg/kg Kanamicine for 14 days.

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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