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Clinical Efficacy and Immunological Mechanism of Immunotherapy for Allergic Rhinitis

Research Project

Project/Area Number 07671878
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionOSAKA CITY UNIVERSITY

Principal Investigator

OHASHI Yoshihiro  Osaka City Univ.Medical school Associate Professor, 医学部, 助教授 (60160602)

Co-Investigator(Kenkyū-buntansha) OHNO Yoshiharu  Osaka City Univ.Medical school Assistant Professor, 医学部, 助手 (00271180)
Project Period (FY) 1995 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 1997: ¥200,000 (Direct Cost: ¥200,000)
Fiscal Year 1996: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1995: ¥1,200,000 (Direct Cost: ¥1,200,000)
Keywordsallergic rhinitis / immunotherapy / T cell / cytokine / IgE synthsis / IgG4 / 免疫療法 / アレルギー性鼻炎 / サイトカイン / IgE抗体 / IgG4抗体 / 接着分子 / allergic rhinitis / specific IgE / specific IgG4 / IL-4
Research Abstract

The aim of the project was to investigate the clinical efficacy of immunotherapy for perennial and seasonal allergic rhinitis and the working mechanisms of the treatment behind the clinical efficacy. First of all, our study documented that immunotherapy can not only alleviate the nasal symptoms of patients with allergic rhinitis, but also cure the disease. A variety of immunological mechanisms were involved in the working mechanis of immunotherapy, which included an induction of apecific blocking Ig G4 antibody, an suppression of T cell hyper-activity, an inhibition of IgE synthesis, a suppression of inflammatory events, and T cell aneryg. However, these different immunological mechanisms were involved in the clinical efficacy of immunotherapy at different phases of the treatment. Immunotherapy suppressed both TH1 and TH2 responses during allergen stimulation. However, the effect of immunotherapy on the TH1 response was not significantly correlated with the symptomatic relief. The suppression of the TH2 response was exclusively related to the clinical efficacy. The conclusion of the study is that a suppression of the allergen-induced TH2 response, especially IL-5 synthesis, is the major mechanism of immunotherapy related to the clinical efficacy.

Report

(4 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • 1995 Annual Research Report
  • Research Products

    (29 results)

All Other

All Publications (29 results)

  • [Publications] Ohashi Y, et al: "Natural course of serum-specific immunoglubulin E and immunoglubulin G4 for a span of eight years in untreated patients with perennial allergic rhinitis." Laryngoscope. 107. 382-385 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ohashi Y, et al: "Serum level of soluble interleukin-2 receptor in patients with seasonal allergic rhinitis." Scadinavian Journal of Immunology. 45. 315-321 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ohashi Y, et al: "Significant correlation between symptom score and IgG4 antibody titer following long-term immunotherapy for perennial allergic rhinitis." Annals of Otology,Rhinology & Laryngology. 106. 483-489 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ohashi Y, et al: "Immunotherapy affects the seasonal increase in specific IgE and interleukin-4 in the serum of patients with seasonal allergic rhinitis." Scandinavian Journal of Immunology. 46. 67-77 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ohashi Y, et al: "Effect of immunotherapy on seasonal changes in serum-specific IgE and IgG4 in patients with pollen allergic rhinitis." Laryngoscope. 107. 1270-1275 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ohashi Y, et al: "Serum levels of specific IgE,soluble interleukin-2 receptor,and soluble intercellular adhesion molecule-1 in seasonal allergic rhinitis." Annals of Allergy,Asthama & Immunology. 79. 213-220 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ohashi Y,Nakai Y,Okamoto H,Ohno Y,Sakamoto H,Sugiura Y,Kakinoki Y,Tanaka A,Kishimoto K, Washio Y,Hayashi M :"Serum level of interleukin-4 in patients with perennial allergic rhinitis during allergen-specific immunotherapy" Scandinavian Journal of Immunology. 43. 680-686 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ohashi Y,Nakai Y,Sakamoto H,Ohno Y,Sugiura Y,Okamoto H,Tanaka A,Kakinoki Y,Kishimoto K,Hayashi M :"Serum levels of soluble interleukin-2 receptor in patients with perennial allergic rhinitis before and after immunotherapy." Annals of Allergy, Asthma&Immunology. 77. 203-208 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ohashi Y,Nakai Y,Ohno Y,Okamoto H,Kakinoki Y,Masamoto T,Tanaka A,Hayashi M :"Natural course of serum-specific immunoglubulin E and immunoglubulin G4 for a span of eight years in untreated patients with perennial allergic rhinitis." Laryngoscope. 107. 382-385 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ohashi Y,Tanaka A,Kakinoki Y,Ohno Y,Sakamoto H,Kato A,Masamoto T,Washio Y,Nakai Y :"Serum level of soluble interleukin-2 receptor in patients with seasonal allergic rhinitis." Scadinavian Journal of Immunology. 45. 315-321 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ohashi Y,Nakai Y,Kakinoki Y,Ohno Y,Okamoto H,Sakamoto H,Kato A,Tanaka A :"The effect of immunotherapy on the serum levels of eosinophil cationic protein in seasonal allergic rhinitis." Clinical Otolaryngology. 22. 100-105 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ohashi Y,Nakai Y,Okamoto H,Ohno Y,Sakamoto H,Tanaka A,Kakinoki Y :"Significant correlation between symptom score and IgG4 antibody titer following long-term immunotherapy for perennial allergic rhinitis." Annals of Otology, Rhinology&Laryngology. 106. 483-489 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ohashi Y,Nakai Y,Tanaka A,Kakinoki Y,Ohno Y,Masamoto T,Sakamoto H,Kato A,Washio Y,Hayashi M :"Soluble intercellular adhesion molecule-1 in sera is elevated in Perennial allergic rhinitis." Laryngoscope. 107. 932-935 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ohashi Y,Nakai Y,Kakinoki Y,Ohno Y,Tanaka A,Sakamoto H,Masamoto T,Washio Y,Kato A :"Immunotherapy affects the seasonal increase in specific IgE and interleukin-4 in the serum of patients with seasonal allergic rhinitis." Scandinavian Journal of Immunology. 46. 67-77 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ohashi Y,Tanaka A,Kakinoki Y,Ohno Y,Sakamoto H,Kato A,Masamoto T,Washio Y,Nakai Y :"Effect of immunotherapy on seasonal changes in serum-specific IgE and IgG4 in patients with pollen allergic rhinitis." Laryngoscope. 107. 1270-1275 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ohashi Y,Nakai Y,Tanaka A,Kakinoki Y,Ohno Y,Masamoto T,Sakamoto H,Kato A,Washio Y,Hayashi M :"Serum levels of specific IgE, Soluble interleukin-2 receptor, and soluble intercellular adhesion molecule-1 in seasonal allergic rhinitis." Annals of Allergy, Asthama & Immunology. 79. 213-220 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ohashi Y,Nakai Y,Morimoto K,Tanaka A,Kakinoki Y,Ohno Y,Masamoto T,Washio Y,Kato A :"Platelet activating factor compromises epithelial defense function in the airway." Journal of Allergy and Clinical Immunology. 100. 520-526 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ohashi Y,et al: "Natural course of serum-specific immunoglubulin E and immunoglubulin G4 for a span of eight years in untreated patients with perennial allergic rhinitis." Laryngoscope. 107. 382-385 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ohashi Y,et al: "Serum level of soluble interleukin-2 receptor in patients with seasonal allergic rhinitis." Scadinavian Journal of Immunology. 45. 315-321 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ohashi Y,et al: "Significant correlation between symptom score and IgG4 antibody titer following long-term immunotherapy for perennial allergic rhinitis." Annals of Otology,Rhinology & Laryngology. 106. 483-489 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ohashi Y,et al: "Immunotherapy affects the seasonal increase in specific IgE and interleukin-4 in the serum of patients with seasonal allergic rhinitis." Scadinavian Journal of Immunology. 46. 67-77 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ohashi Y,et al: "Effect of immunotherapy on scasonal changes in scrum-specific IgE and IgG4 in patients with pollen allergic rhinitis." Laryngoscope. 107. 1270-1275 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ohashi Y,et al: "Serum levels of specific IgE,soluble interleukin-2 receptor,and soluble intercellular adhesion molecule-1 in seasonal allergic rhinitis." Annals of Allergy,Asthama & Immunology. 79. 213-220 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ohashi Y: "Serim levels of interleukin-4 in patients with peremial allergic rhinilis during allergen-specfic immunotherapy." Scandinavian Journal of Immunotherapy. 43. 680-686 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Ohashi Y: "Serum levels of soluble interleukin-2 receptor in patients with peremial allergic rhinitis during immunotherapy." annals of Allergy Asthma & Immunology. 77. 203-208 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 大橋淑宏: "高感度特異的IgE抗体測定法の臨床的評価-LMDによるスギIgE抗体の測定-" 耳鼻咽喉科臨床. 89. 575-581 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 大橋淑宏: "通年性アレルギー性鼻炎に対する免疫療法-長期施行例に対する臨床効果-" 耳鼻咽喉科臨床. 88. 873-881 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] 大橋 淑宏: "通年性アレルギー性鼻炎に対する免疫療法-長期施行例に対する臨床効果-" 耳鼻咽喉科臨床. 88. 873-881 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Ohashi Y: "Sernm levels of soluble interleukin-2 receptor in patients with peremiol allergic rhinitis before and after immuso thorapy" Ann Allergy Immanol. (in press). (1996)

    • Related Report
      1995 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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