| Project/Area Number |
07671983
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Meikai University School of Dentistry |
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Principal Investigator |
TAJIMA Yoshifumi Meikai University School of Dentistry, Associate Professor, 歯学部, 助教授 (80105593)
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| Project Period (FY) |
1995 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1997: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1996: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1995: ¥800,000 (Direct Cost: ¥800,000)
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| Keywords | Chondrocytes / Functional differentiation / Histochemistry / 分化と機能 |
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| Research Abstract |
In this research project, we addressed our interest on the mechanical modulation of the cartilage cell (s) function in accordance with their growth and differentiation. To investigate their mechanism, we studied mandibular condylar and articular cartilages by means of histochemical procedures using a variety of marker for the cartilage cell function. We used the cartilages from hypophysectomized- and ovariectomized rats.
The following results were obtained :
(1) Growth hormone affects the process of cartilage cell glycosylation and subsequent sulfation occurring in the Golgi complexes.
(2) Growth hormone specifically promotes the proliferation phase of the chondrocytes in the proliferative zone in vivo.
(3) Estrogen deficiency at early stages after ovariectomy causes cell proliferation and matrix synthesis in the growth plate cartilage.
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