| Project/Area Number |
07672019
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
HORI Nobuaki Kyushu University Faculty of Dentistry Associate Professor, 歯学部, 助教授 (60037520)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Kenji Kyushu University Faculty of Dentistry Professor, 歯学部, 教授 (40091326)
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| Project Period (FY) |
1995 – 1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1996: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1995: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | pelet food / powder food / long-term potentiation / hipopcampus / field potential / GABA / glutamatr / pyramidal cell / 膜抵抗 |
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| Research Abstract |
We have investigated whether a decrease in masticatory work affected the physiological characteristics of the central nervous system electrophysiologically. Male rats, weaned at 3 weeks of age, were fed either pelted (SL) or powdered (PW) chow until 4 and 10 months of age and electrophysiological experiments were performed on each of feeding groups. Long-term potentiation (LTP) to be believed as learning and memory and synaptic potential were studied in the Schaffer collateral (Sc) -CA1 pathway in an in vitro slice preparation of hippocampus. The sensitivity of transmitters (GABA,glutamate) on the apical dendrites of a pyramidal sell in CA1 was investigated iontophoretically. Experimental results were as follows : (1) Significant change of membrane potentials of the pyramidal cells was not observed between the SL and PW groups. (2) Synaptic potentials recorded from the SL.groups showed more complicated feature than the PW.(3) Dendritic receptor site for GABA and glutamate was localized in the SL group compared to the PW.(4) The amplitude of LTP recorded from the PW group was significantly bigger than from the SL.Results of 2 and 3 mean that in the SL group, neuronal networks develop normally. These results may suggest that strong masticatory works promote the functional development of the central nervous systems.
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