The study of interleukin-4 producing cells in inflamed human gingiva
| Project/Area Number |
07672051
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
病態科学系歯学(含放射線系歯学)
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| Research Institution | KYUSHU UNIVERSITY |
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Principal Investigator |
NAGATA Kengo KYUSHU UNIVERSITY Faculty of Dentistry, Reseach Assistant, 歯学部, 助手 (90189134)
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| Co-Investigator(Kenkyū-buntansha) |
KABASHIMA Hiroaki KYUSHU UNIVERSITY Faculty of Dentistry, Reseach Assistant, 歯学部, 助手 (20214504)
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| Project Period (FY) |
1995 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1997: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1996: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1995: ¥800,000 (Direct Cost: ¥800,000)
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| Keywords | Peridontitis / Interleukin-4 / CD4 positive T cell / Periapical granuloma / インターロイキン・4 |
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| Research Abstract |
The gingival crevicular fluid (GCF) from moderate inflammation sites in patients with periodontal disease predominantly consisted of IL-1alpha. Whereas, we found significantly higher level of IL-1beta in GCF from severe inflammation sites in patients with complaints of spontaneous pain. This suggested that IL-1beta is suspected to play an important role in the amplification of inflammatory process in periodontal disease. We detected IL-1 receptor antagonist (IL-1ra) and IL-4 existing in GCF by an immunochemical method. However, we could not detect IL-4 in GCF from severe inflammation sites. In addition, we sought to detect which cells had produced cytokines in moderately inflamed gingival tissues by means of immunohistochemistry. The cells types expressing CD 68 were identified as monocytes/macrophages and stained positive for IL-1ra. The helper T cells identified by immunostaining for CD4 stained positive for IL-4. These results suggested that IL-4 was to be one of mediators to regulate the degree of local inflammation in periodontal disease.
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Report
(4 results)
Research Products
(4 results)
