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Histologic and Hydrodynamic Evaluation of Blood Flow for Scintigraphic Detection of Malignant Tumor of the Head and Neck.

Research Project

Project/Area Number 07672052
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 病態科学系歯学(含放射線系歯学)
Research InstitutionKagoshima University

Principal Investigator

SATO Tsuyoshi  Kagoshima University, Dept. of Dental Radiology, Associate Professor, 歯学部, 助教授 (90136888)

Co-Investigator(Kenkyū-buntansha) NOIKURA Takenori  Kagoshima University, Dept. of Dental Radiology, Professor, 歯学部, 教授 (40102561)
KAWASHIMA Kiyomi  Kagoshima University, First Dept. of Maxillo-facial Surgery, Research associate, 歯学部, 助手 (40145511)
濱本 定俊  鹿児島大学, 歯学部, 助手 (30244255)
Project Period (FY) 1995 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1996: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1995: ¥1,700,000 (Direct Cost: ¥1,700,000)
KeywordsScintigraphy / Early image / Malignant tumor / Blood flow / Head and Neck / Scintigrashy / Blood flow
Research Abstract

In the experiment with animals, Japan white rabbits transplanted with VX2 carcinoma in the right femoral regionwere examined histologically, angiographically and hydrodynamically. The tumor blood vessel became rich in accordance with tumor growth and the blood flow rate and the volume of the blood flow of the right femoral artery in the tumor side was approximately twice or three times as much as that in the control side (left femoral artery) by means of the ultrasonic blood flow meter (5 MHz). In the clinical examination, 117 patients with oral cancer were examined scintigraphically and histopathologically. Tumor blood flow was estimated scintigraphically immediately after administration of <@D199m@>D1Tc-HMDP.Radioactivity of venous phase (30 to 40 seconds after administration) and blood pool phase (1 to 3 minutes) were observed. Radioactive ratios of tumor to the control region in both phases were calculated ; venous ratio (VR), blood pool ratio (BPR). Early image with <@D199m@>D1Tc-HMDP (early image) was obtained 5 minutes after administration and the image with <@D167@>D1Ga-citrate (Ga-image) was obtained 3 days after administration. Tumor vascular patterns were classified histopathologically into three groups ; rich, intermediate and poor. VR,BPR,early image, Ga-image, vascular pattern and tumor size were compared each other. Poor vascular pattern showed small VR (M(]SY.+-。[)SD=0.97(]SY.+-。[)0.08) and BPR (1.02(]SY.+-。[)0.04). Rich vascular pattern showed large VR (1.39(]SY.+-。[)0.01) and BPR (1.31(]SY.+-。[)0.16). Positive early image was predominant among large VR (78%) and BPR (100%). Tumors of under 3 cm in size showed that 65% of them belonged to intermediate or rich vascular pattern and positive early image reflected tumor blood flow. These results intimated the improvement of detecting ratio by combining early image (blood flow image) with delayd image.

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • Research Products

    (7 results)

All Other

All Publications (7 results)

  • [Publications] T.Sato et al: "Interpretation of scintigraphic findings on the basis of histological vascular system for the detection of malignant twnor" Oral Orcology. IV(A). 75-78 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.Sato,et al: "Scintigraphic detection of oral cancer with early bone scin tigraphy" Oral Radiology. (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] SATO,T., HAYAKAWA,K., NOIKURA,T., SUGIHARA,K., MIMURA,T.: "Interpretation of scintigraphic findings on the basis of histological vascular system for the detection of malignant tumor." Oral Oncology. IV (A). 75-78 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] SATO,T., HAYAKAWA,K., MIYAHARA,M., KAWASHIMA,K., NOIKURA,T., YAMASHITA,S.: "Scintigraphic detection of oral cancer with early bone scintigraphy." Oral Radiology. (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.Sato,et al: "Interpretation of scintigraphic findengs on the basis of histological vascular sustem for the detection of malignant tumor." Oral Ontology. IV(A). 75-78 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] T.Sato,et al: "Scintigraphic detection of oral cancer with early bone scintigraphy" Oral Radiology. (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] T.Sato,et al.: "Interpretation of scintigraphic findings on the basis of histlogical vascular system for the detection of malignant tumor." Oral Oncology. IV"A". 75-78 (1995)

    • Related Report
      1995 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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