The kinetics and role of cytokines in graft-versus-host disease.

Research Project

Project/Area Number	07672058
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	病態科学系歯学(含放射線系歯学)
Research Institution	Ohu University
Principal Investigator	FUJIWARA Kouji Ohu University, Department of Dentistry, Associate Professor, 歯学部, 助教授 (10165433)
Co-Investigator(Kenkyū-buntansha)	YAMASAKI Akira Ohu University, Department of Dentistry, Professor, 歯学部, 教授 (60110459)
Project Period (FY)	1995 – 1996
Project Status	Completed (Fiscal Year 1996)
Budget Amount *help	¥2,500,000 (Direct Cost: ¥2,500,000) Fiscal Year 1996: ¥1,000,000 (Direct Cost: ¥1,000,000) Fiscal Year 1995: ¥1,500,000 (Direct Cost: ¥1,500,000)
Keywords	graft-versus-host disease / cytokines
Research Abstract	To examine the role of interferon-gamma (IFN-gamma) in graft-versus-host disease (GVHD) in non-irradiated (Brown Norway*Lewis) F1 hybrid rats injected with spleen cells from parental strain rats (Brown Norway), we studied the serum level of IFN-gamma and the effect of IFN-gamma administration. An increase in serum IFN-gamma levels was noted on day 7 at which time none of the recipients showed any signs of GVHD,and marked at the time of onset of GVHD.Administration of exogenous IFN-gamma accelerated splenomegaly and the severity of the tongue lesion, but had no significant effect on the time of onset of GVHD and the immnohistological features of the tongue lesion in GVHD rats. These results suggest that IFN-gamma is closely related to the development of GVHD in this rat model.