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The kinetics and role of cytokines in graft-versus-host disease.

Research Project

Project/Area Number 07672058
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 病態科学系歯学(含放射線系歯学)
Research InstitutionOhu University

Principal Investigator

FUJIWARA Kouji  Ohu University, Department of Dentistry, Associate Professor, 歯学部, 助教授 (10165433)

Co-Investigator(Kenkyū-buntansha) YAMASAKI Akira  Ohu University, Department of Dentistry, Professor, 歯学部, 教授 (60110459)
Project Period (FY) 1995 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 1996: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1995: ¥1,500,000 (Direct Cost: ¥1,500,000)
Keywordsgraft-versus-host disease / cytokines
Research Abstract

To examine the role of interferon-gamma (IFN-gamma) in graft-versus-host disease (GVHD) in non-irradiated (Brown Norway*Lewis) F1 hybrid rats injected with spleen cells from parental strain rats (Brown Norway), we studied the serum level of IFN-gamma and the effect of IFN-gamma administration.
An increase in serum IFN-gamma levels was noted on day 7 at which time none of the recipients showed any signs of GVHD,and marked at the time of onset of GVHD.Administration of exogenous IFN-gamma accelerated splenomegaly and the severity of the tongue lesion, but had no significant effect on the time of onset of GVHD and the immnohistological features of the tongue lesion in GVHD rats.
These results suggest that IFN-gamma is closely related to the development of GVHD in this rat model.

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • Research Products

    (3 results)

All Other

All Publications (3 results)

  • [Publications] 杉浦 淳子: "移植片対宿主病におけるIFN-γの役割に関する研究" 奥羽大歯学誌. 23・4. 459-465 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Junko Sugiura: "The role of interferon-gamma in experimental graft-versus-host disease." Ohu University Dental Journal. 23-4. 459-465 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 杉浦淳子: "移植片対宿主病におけるIFN-γの役割に関する研究" 奥羽大歯学誌. 23・4. 459-465 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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