| Project/Area Number |
07672058
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
病態科学系歯学(含放射線系歯学)
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| Research Institution | Ohu University |
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Principal Investigator |
FUJIWARA Kouji Ohu University, Department of Dentistry, Associate Professor, 歯学部, 助教授 (10165433)
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| Co-Investigator(Kenkyū-buntansha) |
YAMASAKI Akira Ohu University, Department of Dentistry, Professor, 歯学部, 教授 (60110459)
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| Project Period (FY) |
1995 – 1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 1996: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1995: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | graft-versus-host disease / cytokines |
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| Research Abstract |
To examine the role of interferon-gamma (IFN-gamma) in graft-versus-host disease (GVHD) in non-irradiated (Brown Norway*Lewis) F1 hybrid rats injected with spleen cells from parental strain rats (Brown Norway), we studied the serum level of IFN-gamma and the effect of IFN-gamma administration.
An increase in serum IFN-gamma levels was noted on day 7 at which time none of the recipients showed any signs of GVHD,and marked at the time of onset of GVHD.Administration of exogenous IFN-gamma accelerated splenomegaly and the severity of the tongue lesion, but had no significant effect on the time of onset of GVHD and the immnohistological features of the tongue lesion in GVHD rats.
These results suggest that IFN-gamma is closely related to the development of GVHD in this rat model.
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