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Effects of antioxidants on the polymerization and lipid peroxidation in dental resin materials

Research Project

Project/Area Number 07672106
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 補綴理工系歯学
Research InstitutionMeikai University

Principal Investigator

FUJISAWA Seiichiro  School of Dentistry, Meikai University, Prof., 歯学部, 教授 (40014162)

Co-Investigator(Kenkyū-buntansha) KADOMA Yoshinori  Tokyo Medical & Dental Uni.Assoc.Prof., 医用器材研究所, 助教授 (00092403)
Project Period (FY) 1995 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1996: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 1995: ¥1,000,000 (Direct Cost: ¥1,000,000)
KeywordsPhotosemsitizer / Camphorquinone / 9-Fluorenon / visible light irradiation / antioxidant / reactive oxgen / ACAS Laser Cytometry / Peroxid indicator / 過酸化ベンゾイル / 重合抑制剤 / 重合禁止作用 / 示差走査熱量計 / ACAS Laser サイトメトリー / メチルメタクリレート / 重合禁止 / 脂質過酸化 / 誘導期間 / 初期重合速度 / α-トコフェロール / β-カロチン
Research Abstract

Benzoyl peroxide, photosensitizer and other redox systems are used as an initiator of the free-radical initiator and propergation of methyl methacrylate polymerization. They cause the damage of cell membranes due to the lipid peroxidation of phospholipids in cell membranes. Antioxidants such as vitamin E,vitamin C,histidine, hydroquinone, etc. They are a scavenger of free radicals. Effets of photosensitizer (camphorquinone CQ,9-fluorenone 9F) in the presense of dimethyl aminoethyl methacrylate (reducing agent) with visible-light irradiation on human submandibular gland adenocarcinoma cell line HSG were investigated by the percentage of cell survival and the production of reactive oxygen measured with ACAS laser cytometer and a peroxide indicator (5- (and 6) -carboxyl-2', 7'-dichloro fluorecin diacetate).
The amount of reactive oxygene generated in the cells irradiated in the 9F system was larger than that of the CQ system.
The decrease in % survival in the 9F system was greater than that in the CQ system. The 9F system gave much stronger damage to the cell than the CQ system due to the production of reactive oxygens.

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • Research Products

    (20 results)

All Other

All Publications (20 results)

  • [Publications] 藤沢盛一郎: "BPOによるメチルメタクリレート重合におよぼすビタミンEの影響" 歯材器. 15. 483-488 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] S.ITO: "NMR studies on dental adhesive monomer.Complete Assignment of ^<13> C-NMR spectrum and gemetrical study of 5-methacryloy aminosahcylic acid" Dental Material Journal. 15. 1-10 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] S Fujisawa: "Action of eugenol as a retarder against polymerization of methylmethacrylate by benzoly peroxicle" Biomaterials. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 藤沢盛一郎: "メチルメタクリレート重合に及ぼすα-トコフェロール、β-カロチンの影響" 歯材器 Special lssue. 15. 38-39 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 藤沢盛一郎: "Eugenol,EBAおよびその関連化合物とCa^<2+>相互作用-NMR研究-" 歯材器 Special lssue. 15. 320-321 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] S.Ito: "Complete BC-NMR assigment of dental adhesive monower 4-inethacryicxy ethyltrimelitate and its hydrate by NMR spetniscopy" Magnetic Resonance in chenistry. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ito, S.: "NMRstudies on dental adhesive monomer complete assignment of 13C-NMR spectrum and geometrical study of 5-methacryloyl aminosalicylic acid." Dent Mater J.15. 1-10 (1966)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ito, S.: "Complete 13C-NMR assignment of dental adhesive monomer 4-methacryloyloxyethyl trimellitate anhydride and its hydrate by NMR spectroscopy, Note to Magnetic Resonance in Chemistry" Magnetic Resonance in Chemistry J Son Co. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Fujisawa S.: "Effects of vitamin E on the polymerization of methyl methacrylate by BPO" JJSDen Mat&Dev. 15,6. 483-488 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Fujisawa S.: "Action of eugenol as aretarder against polymerization of methacrylate by benzoyl peroxide." Biomaterials. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Fujisawa S.: "Effects of alpha tocopherol and beta carotene on the polymerization of methyl methacrylate" JJSDen Mat&Dev specia issue. 27. 38-39 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Fujisawa S.: "NMR study of the interaction of eugenol, EBA and their related compounds with Ca2+" JSDen Mat&Dev Specia issue. 28. 320-21 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 藤沢盛一郎: "BPOによるメチルメタクリレート重合におよぼすビタミンEの影響" 歯材器. 15. 483-488 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] S.Ito.: "NMR studies on dental adhesive monomer compiete assignment of ^<13>C-NMR spectrum and geometrical studies of 5-metha crycith anysis solity tie acid" Dental Mater Journal. 15. 1-10 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] S.Fujisawa: "Action of eugenol as a retarder againist polymerization of methylmetthacrilate by benzoyl peroxide" Biomaterials. (in press).

    • Related Report
      1996 Annual Research Report
  • [Publications] 藤沢盛一郎: "メチルメタクリレート重合に及ぼすα-トコフェロール,β-カロチンの影響" 歯材器 Special Issue. 15. 38-39 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 藤沢盛一郎: "Eugend,EBAおよびその関連化合物noCa^<2+>相互作用-NMR研究" 歯材器 Special Issue. 15. 320-321 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 藤沢盛一郎: "歯科用接着性モノマーとCa^<2+>相互作用のNMR研究(その2) 5-(N-methacryloylamino salicylic acidについて" 歯科材料器材. 14 speciul issue 25. 42-43 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 藤沢盛一郎: "歯科用接着性モノマーとCa^<2+>相互作用のNMR研究(その3) 4-METAおよびその関連化合物とCaHPO_4・2H_2Oとの相互作用" 歯科材料器材. 14 special issue 26. 188-189 (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] 増田屯: "口腔診断学入門" 医学情報社, 220 (1996)

    • Related Report
      1995 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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