| Project/Area Number |
07672119
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
補綴理工系歯学
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| Research Institution | Kagoshima University |
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Principal Investigator |
NAGAOKA Eiichi Kagoshima University, Dental School, Professor, 歯学部, 教授 (00028812)
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| Co-Investigator(Kenkyū-buntansha) |
HARUNO Masatoshi Kagoshima University, Dental School, Research Associate, 歯学部, 助手 (00274845)
迫田 敏 鹿児島大学, 歯学部, 助手 (00235235)
河野 弘 鹿児島大学, 歯学部・附属病院, 助手 (00234708)
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| Project Period (FY) |
1995 – 1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1996: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1995: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | Edentulous Ridge / Changes after Extraction / Bone Mineral Density / Histomorphometry |
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| Research Abstract |
This study was conducted to investigate the edentulous bone metabolism of beagle dogs. Thirteen female beagle dogs had all premolars extracted and were sacrificed after 3 months (n=3), 4 months (n=1), 5 months (n=3), 6 months (n=2) and 9 months (n=4). Dogs were double-labeled with tetracycline and calcein, 14 days and 7 days prior to sacrifice, respectively. Mandibles were dissected and analyzed with dual energy X-ray absorptiometry. Bone mineral density (BMD) was measured in the edentulous region. Subsequently, the edentulous bone located at the second premolar was processed undecalcified for bone histomorphometry. The parameters were measured in the cancellous bone area 250 mum from the endosteal surface. The following parameters were measured ; trabecular Bone Volume (BV/TV), Feret X/Y and Marrow Area for bone structure, Mineralizing Surface (MS) for bone formation and Osteoclast Surface (OS/BS) for bone resorption. The sequential changes of measured values from 3 months to 9 months after extraction were analyzed by the Spearman rank correlation. Additionally, the differences between two groups of 3 months, 5 month and 9 month group were evaluated by the Mann-Whitney U test. The results of the BMD measurements showed a successive decrease during the experimental period. The values of histomorphometric measurement exhibited an increase of BV/TV,Feret X/X and Marrow Area, and a decrease of MS and OS/BS.It may be suggested that structure of trabecular bone which changed repidly corresponded to the alteration of mechanical status caused by tooth loss.
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