| Project/Area Number |
07672166
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | KYOTO UNIVERSITY |
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Principal Investigator |
NISHIDA Mitsuo Kyoto University, Faculty of Medicine, Assistant Professor, 医学研究科, 講師 (50154620)
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| Co-Investigator(Kenkyū-buntansha) |
YOKOE Yoshihiko Kyoto University, Faculty of Medicine, Assistant Professor, 医学研究科, 助手 (30211650)
SEGAMI Natsuki Kanazawa Medical University, Faculty of Stomatology, Professor, 口腔科学講座, 教授 (40148721)
MURAKAMI Ken-ichiro Kyoto University, Faculty of Medicine, Assosiate Professor, 医学研究科, 助教授 (00174269)
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| Project Period (FY) |
1995 – 1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1996: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1995: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | Intraoperative Radiotherapy / Intraoperative Irradiation / Tumor Marker / Oral Cancer / Advanced Oral Cancer |
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| Research Abstract |
Study for identification of residual cancer area of the oral advanced carcinomas at intraoperative radiotherapy was performed. Concernig treatment modality on oral squomous cell carcinomas, chemotherapy is appeared aduvant means and actively used only for palliative treatment of nonsquomous cell carcinomas in the head and neck cancer. However, these tumor are relatively rare and, then actually a modality of combination therapy with radiation therapy and surgery may be recommended. In this combination therapy, for advanved oral squomous cell carcinomas radiation therapy was usually employed as preoperative one in our department, and acceptable five year survival rate has been obtained. However, severely advanced carcinomas such as invasive tumor to the internal or common carotid artery or to the deep cervical fascia, intraoperative radiotherapy is a intensive modality to treat these adhesive carcinomas, and there is a few reports applied intraoperative radiotherapy to head and neck carcinomas, we think this type of treatment is suitable in this region. Clinical application of intraoperative radiotherapy was reported from our department in 1996. However, some problems with this therapy remained regarding to adaptation between operative field and X-ray cone, depth and area of irradiation effect. So, we have considered application of lridium-192 as well as intraoperative radiotherapy. It is usually obtained as seeds loaded into a flexible nylon sheath, or thin flexible wire sources used in the form of a "hairpin". The strength and interspacing of the sources can be altered to suit individual case requirements. The other hand, as study for identification of residual cancer area of the oral advanced carcinomas at intraoperative radiotherapy, suitable material for the purpose have been serched by applying to various intraoral tumor specimen with immunohistochemical method.
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