| Project/Area Number |
07672185
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
|
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| Research Institution | Showa University |
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Principal Investigator |
KUNO Masatoshi Showa university, school of Dentistry, assistant Prof., 歯学部, 講師 (20119184)
|
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| Co-Investigator(Kenkyū-buntansha) |
陳 光輝 昭和大学, 歯学部, 助手 (40231427)
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| Project Period (FY) |
1995 – 1996
|
| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1996: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1995: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | Hemodilution / Hypotension / Tissue PO_2 / Nitroprusside / SalineHes / 血中希釈 / ニトロプロシド / 組織PO_2 / 心筋 / 乳酸 / ピルビン酸 |
|---|
| Research Abstract |
Hemodynamic changes and tissue PO_2 response under acute hemodilution and controlled hypotension was studied in mongral dogs anesthetized with sevoflurane and paralized pancuronium. Hemodilution was produced by removal of 20ml/kg whole blood and ingusing 6%hydroxyethyl starch saline at 1.5times the volume of blood removed. Subsequenthy hypotension to a mean blood pressure 70mmHg was induced for 90minutes by intravenous infusion of Sodium nitroprusside. The results were as follows.
1. Pluse rate was sloght decreused after hemodilution, but should no changes during hypotension.
2. CI significant incresed after hemodilution but should no significant changes during hypotension.
3. Renal blood flow significantly increased after hemodilution.
4. Renal cortex and medilla tissue PO_2 significantly decrused.
Hemodynamic changes should no significant after hemodirution and during hypotension.
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