| Project/Area Number |
07672186
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Surgical dentistry
|
|---|
| Research Institution | TOKYO DENTAL COLLEGE |
|---|
Principal Investigator |
TAKAKI Takashi Tokyo Dental College Department of Dentistry Lecturer, 歯学部, 講師 (90192145)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KOUDA Hidetoshi Tokyo Dental College Department of Dentistry assistant, 歯学部, 助手 (10271298)
KATAKURA Akira Tokyo Dental College Department of Dentistry assistant, 歯学部, 助手 (10233743)
|
|---|
| Project Period (FY) |
1995 – 1996
|
| Project Status |
Completed (Fiscal Year 1996)
|
| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1996: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1995: ¥1,900,000 (Direct Cost: ¥1,900,000)
|
|---|
| Keywords | carcinoma of the tongue / growth pattern / tongue muscle / three dimentional imaging / ヒト舌扁平上皮癌 / 腫瘍の浸潤方向 |
|---|
| Research Abstract |
This study removed primary squamous-cell carcinoma on the lingual margin, and visualized the sequential samples from the border area between the tumor and host as computerized three-dimensional reconstructed images to examine how the progress forms of various tumors with different invasion mechanisms are related to the intrinsic lingual muscle direction at the progress site.
The tumors invaded into the lingual muscular tunics in three modes : invasion of the tumor alveolar structure with interstitial tissues, which presses muscular fibrous fascicles (Type 1), diffuse invasion of the tumor into the pores of the muscular fibrous fascicles with or without the funicular, alveolar structure formed by the tumor (Type 2), and the invasion of the tumor into muscular fibrous fascicles (Type 3).
The tumors showing the Type 1 progress mode showed no relation between tumor progress form and intrinsic lingual muscle direction. Type 1 was observed in both the type 2 and 3 invasion modes, which indicates that tumors with limited invasion tend to follow the Type 1 progress mode. The tumors showing the Type 2 progress mode irregularly invaded the pores of the muscular fibrous fascicles. Some of them progressed in the same direction as that of the superficial lingual muscle. Type 2 was observed in the type 4C and 4d invasion modes, indicating that tumors with high invasion tend to follow the Type 2 progress mode. Tumors showing the Type 3 progress mode indicated that small masses consisting of the tumor cells and interstitial tissues progressed in the same direction as that of the muscular fibers in the muscular fibrous fascicles. Type 3 was observed in type 4D invasion, which suggests a relation to invasion intensity.
An examination of the excision area showed that a uniform safety zone around the tumor would be necessary for Type 1. For Type 2 and 3, a wider safety zone in the direction of the lingual muscle would be necessary because the tumor tends to progress in that direction.
|
