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A QUESTFOR BETTER GENERALANESTHESIA TARGETING HEMODYNAMICSTABILITY FOR ORAL SURGEI

Research Project

Project/Area Number 07672189
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionTOKYO DENTAL COLLEGE

Principal Investigator

ICHINOHE Tatsuya  TOKYO DENTAL COLLEGE DEPARTMENT OF DENTISTRY ASSISTANT PROFESSOR, 歯学部, 助教授 (40184626)

Project Period (FY) 1995 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1997: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1996: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1995: ¥1,700,000 (Direct Cost: ¥1,700,000)
KeywordsNoxious stimulation / Hemodynamic response / Nitrous oxide / Isoflurane / Fentanyl / Clonidine / Neostigmine / L-phenylisopropyladenosine / ペンタゾシン / プロポフォール / ケタミン / trigeminal depressor response / エピネフリン / 大脳皮質組織血流量 / 大脳皮質組織酸素分圧
Research Abstract

Systolic blood pressure (SBP) showed biphagic (depressor followed by pressor) responses following electrical stimulation of the mental nerve in rabbits. Depressor response, known as the trigeminal depressor response, was prominent after low frequency stimulations. Changes in cerebral cortex regional blood flow (rCBF) and tissue oxygen tension during the TDR was similar to those during electrical vagal nerve stimulation.Nitrous oxide ameliorated this rCBF reduction.Isoflurane at 1.5 minimum alveolar concentration with or without nitrous oxide inhibited these depressor and pressor responses at the cost of normotension. Fentanyl inhibited depressor response, whereas clonidine, neostigmine and L-phenylisopropyladenosine inhibited pressor response. Clonidine and L-phenylisopropyladenosine produced dose-dependent SBP reduction. Pentazocine, in contrast to fentanyl, inhibited pressor response. Propofol and ketamine also inhibited pressor response. These results suggest that appropriate combinations of these drugs which act at different site of the nociceptive mechanisms may result in safe and effective anesthesia for oral surgery.

Report

(4 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • 1995 Annual Research Report
  • Research Products

    (22 results)

All Other

All Publications (22 results)

  • [Publications] Ichinohe T et al.: "Trigeminal depressor response produces cerebral blood flow reduction in rabbits" Anesth Analg. 82. S197 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ichinohe T et al.: "The effects of nitrous oxide and isoflurane on the somatosympathetic reflxes during electrical stimulation of the mental nerve in rabbits" Anesth Analg. 84. S498 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ichinohe T et al.: "Cerebral cortex regional blood flow and tissue oxygen tension during the trigeminal depressor response in rabbits" J Autonom Nerv Syst. 66. 111-118 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ichinohe T et al.: "Mucosal blood flow during various intravenous and inhalational anesthetics in the rabbit" Oral Surg Oral Med Oral Pathol Oral Radiol Endod. (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 一戸 達也 ら: "急激な血圧低下と大脳皮質組織血流量および酸素分圧との関係" 日歯麻誌. 26. 36-42 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ichinohe T et al.: "The effects of isoflurane and nitrous oxide on the somatosympathetic reflex following electrical stimulation of the mental nerve in rabbits" Anesth Analg. (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ichinohe T et al.: "Trigeminal depressor response produces cerebral blood flow reduction in rabbits" Anesth Analg. 82. S197 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ichinohe T et al: "The effects of nitrous oxide and isoflurane on the somatosympathetic reflex during electrical stimulation of the mental nerve in rabbits" Anesth Analg. 84. S498 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ichinohe T et al.: "Cerebral cortex regional blood flow and tissue oxygen tension during the trigeminal depressor response in rabbits" J Autonom Nerv Syst. 66. 111-118 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ichinohe T et al.: "Mucosal blood flow during various intravenous and inhalational anesthetics in the rabbit" Oral Surg Oral Med Oral Pathol Oral Radiol Endod. (in press). (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ichinohe T et al.: "Cerebral cortical regional blood flow and tissue oxygen tension during acute hypotension" J Jpn Dent Soc Anesthesiol. 26. 36-42 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ichinohe T et al.: "The effects of isoflurane and nitrous oxide on the somatosympathetic reflex following electrical stimulation of the mental merve in rabbits" Anesth Analg. (in submission). (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ichinohe T de al.: "Cerebral cortex regional blood flow and tissue oxygen tension during the trigeminal depressor respons in rabbits" J Autonom Nerv Syst. 66. 111-118 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ichinohe T et al.: "Mucusal blood flow during various intravenous and inhalational anesthetics in the rabbit" Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 85. (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 一戸達也ら: "兎の口腔領域侵害刺激に対する循環応答とネオスチグミンの応答抑制効果" 日歯麻誌. 25. 606 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 一戸達也ら: "兎オトガイ神経電気刺激児にL-phenyl isopropy ladenosineの効果" J Anesth. 12. (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 一戸達也ら: "急激な血圧低下を大脳皮質組織血流量および酸素分圧との関係" 日歯麻誌. 26. 36-42 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 一戸達也ら: "兎の口腔領域侵害刺激に対する循環応答と笑気およびイソフルランの応答抑制効果" 日本歯科麻酔学会雑誌. 24(4). 743- (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Ichinohe T et al.: "The effects of nitrous oxide and isoflurane on the somatosympathetic reflxes during electrical stimulation of the mental nerve in rabbits" Anesthesia and Analgesia. 84(2S). S498- (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] 一戸達也ら: "兎オトガイ神経電気刺激時の循環応答に対するフェンタニールおよびクロニジンの効果" 麻酔.

    • Related Report
      1996 Annual Research Report
  • [Publications] 一戸達也: "Trigeminal depressor response, 迷走神経刺激およびATP静注による血圧低下時の循環動態の比較" Journal of Anesthesia. 10suppl. 337- (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Ichinohe T: "Trigeminal depressor response produces cerebral blood flow reduction in rabbits" Anesthesia and Analgesia. 82. S197- (1996)

    • Related Report
      1995 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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