| Project/Area Number |
07672275
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
|
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| Research Institution | Kumamoto University |
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Principal Investigator |
NOHARA Toshihiro Kumamoto University, Pharmaceutical Sciences, Prof.Dr., 薬学部, 教授 (30037600)
|
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| Project Period (FY) |
1995 – 1996
|
| Project Status |
Completed (Fiscal Year 1996)
|
| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1996: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1995: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | sugar linkage transport / preparation of new functional substance / beta-fabatiose / beta-mimosatetraose / glycosylation / diosgenin glycoside / oleanene glycoside / グリコシデーション / Julibroside I |
|---|
| Research Abstract |
When a fabatriosyl moeity, the most popular sugar linkage attached to C-3 OH of the leguminous oleanene glycosides, was taken off, the activity of antihepatitis was decreased, therefore, it was supposed that a sugar linkage might contribute to express activity. The fabatriosyl residue was cut off with glycyrrhinic acid hydrolase and subsequently attached to other steroidal sapogenol, diosgenin, to give a new glycoside which was shown to have a strong activity. This method would be one way to approach for disclosing the biological roles of the sugar moiety in molecular level.
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