| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1996: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1995: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Research Abstract |
The following compounds were isolated from Emericella sp. From E.purpurea, two new sesterterpenes designated variecolol and variecolic acid and three new yellow 2,3-dicyano-1,4-diphenyl-1,3-butadiene derivatives, epurpurins A-C,were isolated along with the sesterterpene, variecolin, which has angiotensin II binding inhibitory activity. The dicyanide derivatives had the growth inhibitory activity for L1210 cells. Six new hydrogenated azaphilones, falconensin E-G and I-N,and two new pigments with a long conjugated system, EF-Y1 and EF-Y2, were isolated along with the azaphilones from the mycelium of E.falconensis and/or E.fruticulosa. These falconensins will be expected the inhibitory activity for tumor promotor. From the culture medium of E.heterothallica, new 18,22-cyclosterols, emesterols B and C,were isolated along with emesterol A,which had the strong antifungal activty against Aspergillus fumigatus. A new epitetrathiodioxopiperazine, secoemestrin C,was isolated from the early stage of the culture broth of E.foveolata.
From the ascostromata of Talaromyces austrocalifornicus, an azaphilone and a hydrogenated anthraquinone dimer was isolated. A hydroganated azaphilone derivatives and an anthraquinone dimer, skyrin, were also isolated from T.wortmanni. From the ascostromata of Petromyces muricans, four new bisindolylbenzene derivatives, petromurin A-D,a bisindolylbenzoquine (asteriiquinone), Pm-53, and an indoloditerpene, petromindole, were isolated.
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