Synthetic Studies on Biologically Active Poly-Functionalized Carbazoles
Project/Area Number |
07672303
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Chemical pharmacy
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Research Institution | Fukuyama University |
Principal Investigator |
HIBINO Satoshi Fukuyama University Faculty of Pharmacy and Pharmaceutical Sciences Professor, 薬学部, 教授 (60112885)
|
Co-Investigator(Kenkyū-buntansha) |
SUGINO Eiichi Fukuyama University Faculty of Pharmacy and Pharmaceutical Sciences Associate Pr (00179144)
CHOSHI Tominari Fukuyama University Faculty of Pharmacy and Pharmaceutical Sciences Research Ass (10248297)
|
Project Period (FY) |
1995 – 1996
|
Project Status |
Completed (Fiscal Year 1996)
|
Budget Amount *help |
¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1996: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1995: ¥600,000 (Direct Cost: ¥600,000)
|
Keywords | carbazole alkaloid / carazostatin / hyellazole / carbazoquinocins B-F / synthesis / electrocyclic reaction / allene intermediate / oxazolocarbazole |
Research Abstract |
1. The free radical scavenger carazostatin and the marine alkaloid hyellazole have been synthesized by a new type of allene-mediated electrocyclic reaction involving the indole 2,3-bond as a key step. 2. New tetracyclic oxazolo [4,5-c] carbazole and oxazolo [5,4-c] carbazole ring systems as functionalized precursors to antioxidative antiostatins (A_<1-4> and B_<2-5>) and carbazoquinocins (A-F) were synthesized. 3. A new benzo-annelation method based on the allene-mediated electrocyclic reaction of 2,3-functionalized indoles provides an effective route to the highly-functionalized carbazole ring, and the total syntheses of carazostatin, hyellazole and carbazoquinocins B to F have been completed. Moreover, the first total syntheses of carbazoquinocins B,C,E and F were demonstrated.
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Report
(3 results)
Research Products
(10 results)