• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Study on apo A-IV polymorphism in patients with hyperlipidemia.

Research Project

Project/Area Number 07672485
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory medicine
Research InstitutionGifu University

Principal Investigator

SEISHIMA Mitsuru  Div.Central Lab.Gifu Univ.School.Med.Assis.Prof., 医学部・附属病院, 講師 (10171315)

Co-Investigator(Kenkyū-buntansha) SAITO Kuniaki  Dep.Lab.Med.Gifu Univ.Schol.Med.Instructor, 医学部, 助手 (80262765)
NOMA Akio  Dep.Lab.Med.Gifu Univ.Schol.Med.Prof., 医学部, 教授 (30208384)
Project Period (FY) 1995 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1996: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1995: ¥1,400,000 (Direct Cost: ¥1,400,000)
KeywordsApo A-IV / Polymorphism / Hyperlipidemia
Research Abstract

We compared the frequencies of apo A-IV polymorphism at codon 347 and 360 in 40 hyperlipidemic patients with 131 healthy controls. All healthy controls and hyperlipidemic patients studied here had Thr/Thr at codon 347. This result was different with a report in Western, which showed the frequency of Ser allele was 0.144 to 0.216. On the other hand, the frequency of Gln/llis at codon 360 in hyperlipidemic patients was 17.5%, which was lower than 22% in controls although there was no statistical difference between them. It is well known that Gln/Gln and His/His at codon 360 are corresponded to A-IV-1 and A-IV-2, respectively at protein level. It has been reported that subjects with A-IV-2 show higher HDL-C and LCAT activity compared to those with A-IV-1.
In addition, A-IV-2 regulates cholesterol absorbtion in the small intestine. These isoforms, thus, have different functions in the lipid metabolism. In view of this point, few frequency of Gln/His (A-IV-2) in hyperlipidemic patients may indicate that this varient is associated with the cause for hyperlipidemia. However, in the present study, we could not find the difference in the frequency of apo A-IV polymorphism among subtypes of hyperlipidemia, but further study will be necessary in large scale of number.

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • Research Products

    (15 results)

All Other

All Publications (15 results)

  • [Publications] Seishima, M. et al.: "Reduced intestinal apo A-IV mRNA levels in patienta with liver cirrhosis" Int. Hepatol. Commun.4. 153-159 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Seishima, M. et al.: "Reduction of intestinal apo A-IV mRNA levels in the cirrhotic rat" J. Hepatol. Gastroenterol.11. 746-751 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Nishimura, M. et al.: "Effects of lipid administration on lymphatic apolipoprotein A-IV and B output and synthesis" Am. J. Physiol.271. G322-G329 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Saito, K., et al.: "Marked increase in concentrations of apolipoprotein in the cerebrospinal fluid of poliovirus-infected macaques : relations between apolipoprotein concentrations and severity of brain injury" Biochem. J.321. 145-149 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Seishima, M.et al.: "Reduced intestinal apo A-IV mRNA levels in patients with liver cirrhosis" Int.Hepatol.Commun. 4. 153-159 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Seishima, M.et al.: "Reduction of intestinal apo A-IV mRNA levels in the cirrhoticrat" J.Hepatol.Gastroenterol.11. 746-751 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Nishimura, M.et al.: "Effects of lipid administration on lymphatic apolipoprotein A-IV and B output and synthesis" Am.J.Physiol.271. 322-329 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Saito, K.et al.: "Marked increase in concentrations of apolipoprotein in the cerebrospinal fluid of poliovirus-infected macaques : relations between apolipoprotein concentrations and severity of brain injury" Biochem.J.321. 145-149 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Seishima,M.et al.: "Reduced intestinal apo A-IV mRNA levels in patients with liver cirrhosis" Int.Hepatol.Commun.4・3. 153-159 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] Seishima,M.et al.: "Reduction of intestinal apo A-IV mRNA levels in the cirrhotic rat" J.Hepatol.Gastroenterol.11・8. 746-751 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Nishimura,M.et al.: "Effects of lipid administration on lymphatic apolipoprotein A-IV and B output and synthesis" Am.J.Physiol.271・8. G322-G329 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Saito,K.,et al.: "Marked increases in concentrations of apolipoprotein in the cerebrospinal fluid of poliovirus-infected macaques : relations between apolipoprotein concentrations and severity of brain injury" Biochem.J.321・1. 145-149 (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Mitsuru Seishima, et al.: "Reduced intestinal apo A-IV mRNA levels in patients with liver cirrhosis" Intern′t Hepatol. Commun.4. 153-159 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Mitsuru Seishima, et al.: "Reduction of intestinal apo A-IV mRNA levels in the cirrhotic rat" J. Gastroenterol. Hepatol.(in press).

    • Related Report
      1995 Annual Research Report
  • [Publications] Masato Nishimura, et al.: "The effects of lipid administration on lymphatic apo A-IV and apo B outputs and on their syntheses" Am. J. Physiol.(in press).

    • Related Report
      1995 Annual Research Report

URL: 

Published: 1995-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi