| Project/Area Number |
07680075
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
家政学
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| Research Institution | THE NATIONAL INSTITUTE OF HEALTH&NUTRITION |
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Principal Investigator |
YANO Tomohiro THE NATIONAL INSTITUTE OF HEALTH&NUTRITION APPLIED FOOD RESEARCH SENIOR,RESEARCHER, 応用食品部, 主任研究官 (50239828)
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| Co-Investigator(Kenkyū-buntansha) |
ICHIKAWA Tomio MUKOGAWA WOMEN'S UNIVERSITY LIFE ENVIROMENTAL SCIENCE,PROFESSOR, 生活環境学部, 教授 (10028839)
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| Project Period (FY) |
1995 – 1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1996: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1995: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | Lung adenocarcinoma / Chemoprevention / Vitamin E / ras gene / Ornithine decarboxylase / Cell proliferation |
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| Research Abstract |
The intake of vitmain E-supplemented diet which contained the vitamin about10-20 fold compared to control diet could significantly reduced the development of lung adenocarcinoma in mice. When this vitamin E-supplemented diet was provided, the increases of ornithine decarboxylase (ODC) activity, polyamine biosynthesis and proliferating cell nuclear antigen as markers of cell proliferation were almost suppressed. Immunohistochemical study using anti-ODC suppported viochemical results related to cell proliferation at the early stage of lung carcinogenesis. Vitamin E-dependent inhibition of prostaglandin E_2 production at an early stage of lung carcinogenesis contributed to a portion of the suppression of these events related to cell proliferation. Also, vitamin E reduced the frequency of K-ras mutation at the early stage of teh carcinogenesis which was a major event leading to the development of adenocarconoma. Overall, within the possible intake level in daily life, vitamin E could reduce the development of lung adenocarcinoma due to the regulation of cell proliferation during the carcinogenic process.
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