The study of exercise treatment for cardiovascular diseases
| Project/Area Number |
07680102
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
体育学
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| Research Institution | TOKYO METROPOLITAN UNIVERSITY (1997)
The University of Electro-Communications (1995-1996) |
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Principal Investigator |
IZAWA Tetsuya Graduate School of Science, TOKYO METROPOLITAN UNIVERSITY,Professor, 理学研究科, 教授 (70147495)
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| Project Period (FY) |
1995 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1997: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1996: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1995: ¥800,000 (Direct Cost: ¥800,000)
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| Keywords | SHR rat / exercise training / thoracic aorta / endothelium / adipocyte / lipolysis / SHR / ノルエピネフリン / 身体トレーニング / ラット / 心筋細胞 / カルシウム / カルモジュリン / 急性運動負荷 / アンギオテンシンII / 血管内皮由来弛緩因子 |
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| Research Abstract |
The effects of chronic physical exercise (ET) on the sensitivity of thoracic aorta to norepinephrine and on adipocyte lipolysis were investigated in spontaneously hypertensive rats (SHR). After ET, the attenuated sensitivity of aorta to norepinephrine was observed in SHR rats as well as in normotensive rats. This attenuated sensitivity of aorta to norepinephrine after ET was still evident in endothelium-denuded aorta, but to a lesser extent than in endothelium-intact aorta. No significant difference in 60 mM KC1-induced tension between control and trained SHR rats was observed with or without endothelium after ET.The results suggest that levels of endothelium-dependent releasing factor may increase in response to norepinephrine after ET in SHR rats as well as in normotensive rats. In the separate experiments, adipocyte lipolysis was investigated in SHR rats after ET.Adipocyte lipolysis stimulated by various agonists, such as isoproterenol, dobutamine, salbutamol, BRL37344 and dibutyryl cyclic AMP, was blunted in non-trained SHR rats compared with normotensive rats. However, ET significantly increased adipocyte lipolysis stimulated by each agonist, although the maximal responses were less in SHR rats than in normotensive exercise-trained rats. Thus, ET significantly alter the responses of aorta to norepinephrine and those of adipocyte lipolysis to various agonists in SHR rats.
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Report
(4 results)
Research Products
(5 results)
