• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Study on a specific recognition mechanism for mugineic acid-Fe (III) complex in gramineous plants

Research Project

Project/Area Number 07680642
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Bioorganic chemistry
Research InstitutionSuntory Institute for Bioorganic Research (SUNBOR)

Principal Investigator

NOMOTO Kyosuke  Suntory Institute for Bioorganic Research (SUNBOR), Chief Chemist, 部長研究員 (60142080)

Co-Investigator(Kenkyū-buntansha) MA Jian Feng  Okayama Univ., Research Inst.for Boiresources, Assistant Prof.,, 資源生物科学研究所, 助手 (80260389)
IWASHITA Takashi  Suntory Institute for Bioorganic Research (SUNBOR), Chief Chemist, 主任研究員 (00150144)
Project Period (FY) 1995 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1997: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1996: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1995: ¥900,000 (Direct Cost: ¥900,000)
KeywordsMugineic Acids / Phytosiderophores / Chelators / Gramineous Plants
Research Abstract

In order to elucidate a molecular structure of plasma membrane-located transporter for mugineic acid-Fe (III) complex, a few mugineic acid analogs were first synthesized in the present study.
(1) The systhesis of 3'(S) -N- [3-carboxy- (3-carboxypropylamino) propyl] glycine was performed by reductive coupling in the presence of NaBH_3CN of three units, i.e., gamma-butyrolactone, L-homoserine, and glycine. In a similar manner as above, 2 (S), 3'(S) -N- [3-carboxy- (3-carboxypropylamino) propyl] homoserine was synthesized by the condensation of the protected L-N- (3-carboxyprpyl) homeserine aldehyde with L-homoserine lactone in the presence of NaBH_3CN.
(2) The synthesis of 3'(S), 3"(S) -N- [3-carboxy- (3-amino-3-carboxypropylamino) propyl] glycine was achieved by reductive coupling in the presence of NaBH_3CN of three units, namely glycine and 2 molecular L-homoserine lactone. 2 (S), 3'(S), 3"(S) -N- [3-carboxy- (3-amino-3-carboxypropylamino) propyl] homo-serine was similarly synthesized by the condensation of the protected 3'(S) -N- [3-amino-3-carboxyprpyl) homoserine aldehyde with L-homeserine lactone in the presence of NaBH_3CN.
(3) Furthermore, the synthesis of 3'(S), 3"(S) -N- [3-carboxy- (3-carboxy-3-hydroxypropyl) aminopropyl] glycine was carried out by reductive condensation in the presence of NaBH_3CN of three units, ie., L-alpha-hydroxy-gamma-butyrolactone prepared from L-malic acid, L-homoserine aldehyde derived from L-aspartic acid and glycine. 3'(S), 3"(R) -N- [3-carboxy- (3-carboxy-3-hydroxypropyl) aminopropyl] glycine was similarly synthesized by the condensation of the protected 3'(S) -N- (3-carboxy-3-aminopropyl) glycine with D-alpha-hydroxy-gamma-butyrolactone prepared from D-malic acid in the presence of NaBH_3CN.

Report

(4 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • 1995 Annual Research Report
  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] 馬建 鋒・野本 享資: "植物における鉄輸送体" 李刊化学総説・生物無機化学の新展開. 24. 190-201 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] T.F.Ma, T.Shimada, C.Matsuda, and K.Nomoto: "Biosynthesis of Phytosiderophores,Mugincic Acids,Associated with Methionine Cycling" The Journal of BiologicalChemistry. 270. 16549-16554 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] I.F.Ma and K.Nomoto: "Effective regulation of iron aquisition in graminaceous plants.The role of mugineu acids as Phytosiderophores" Physialogia Plantarum. 97. 609-617 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 馬 建鋒・野本 享資: "イネ科植物の鉄獲得戦略 ムギネ酸を軸とした巧みな機構が存在" 化学と生物. 34. 633-635 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Jian Feng Ma and Kyosuke Nomoto: "Mugineic acids : siderophores from gramineous plants" KIKAN KAGAKU SOSETSU. 24. 190-201 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Jian Feng Ma, Tetsuro Shinada, Chitose Matsuda and Kyosuke Nomoto: "Biosynthesis of phytosiderophores, Mugineic acids, associated with methionine cycling" J.Biol.Chem.270. 16549-16554 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Jian Feng Ma and Kyosuke Nomoto: "Effective regulation of iron acquisition in graminaceous plants. The role of mugineic acids as phytosiderophores" Physiol.Plant.97. 609-617 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Jian Feng Ma and Kyosuke Nomoto: "Efficient strategy of iron acquisition by secretion of mugineic acids in graminaceous plants" KAGAKU TO SEIBUTSU. 34. 633-635 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Jian Fong Ma and Kyosuke Nomoto: "Effective regulation of iron acquisition in graminaceous Plants. The role of mugineic acids as Phytosiderophores" Physialogia Plantarum. 97. 609-617 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 馬建鋒・野本享資: "イネ科植物の鉄獲得戦略ムギネ酸を軸とした巧みな機構が有在" 化学と生物. 34. 633-635 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 馬建鋒・野本享資: "植物における鉄輸送体" 季刊化学総説・生物無機化学の新展開. 24. 190-201 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] J. F. Ma, T. Shinada, C. Matsuda, and K. Nomoto: "Biosynthesis of Phytosiderophores, Mnginei Acids, Associated with Methionine Cycling" The Journal of Biological Chemistry. 270. 16549-16554 (1995)

    • Related Report
      1995 Annual Research Report

URL: 

Published: 1995-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi