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Direct detection of brain function using magnetic resonance imaging

Research Project

Project/Area Number 07680714
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Biophysics
Research InstitutionGifu University

Principal Investigator

KUWATA Kazuo  Gifu University School of Medicine, Assistant Professor, 医学部, 助教授 (00170142)

Co-Investigator(Kenkyū-buntansha) NAKAMURA Koji  Gifu University, School of Medicine, Assistant, 医学部, 助手 (70242724)
ERA Seiichi  Gifu University, School of Medicine, Professor, 医学部, 教授 (30152002)
Project Period (FY) 1995 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1997: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1996: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1995: ¥1,100,000 (Direct Cost: ¥1,100,000)
KeywordsMRI / MTC / BOLD effect / task sequence / brain function / fMRI / recognition / will / EPI / 認知 / 迷走神経 / 脳機能イメージング / 水和
Research Abstract

Transient magnetization transfer phenomena was theoretically formulated and analyzed in order for the clinical application of MTC to detect the brain function directly. It was found to be possible to analyze the transient MTC effect by assuming the pseudo-steady state in MTC explicitly incorporating the T_1 discrimination effect. Acquisition parameters in MTC imaging sequence was optimized using the simulation of the theoretical formalism. A fortran program was coded to extract the relevant relaxation parameters from the off-resonance dispersion curve using the non-linear curve fitting procedure. Currently we are applying this technique to detect the brain activation during various tasks in EPI image sequence where MTC contribution, which reflects neuronal excitation directly, would be superimposed on the BOLD effect.
On the other hand, we designed a new mutli-dimensional task sequence by which we can separate multiple tasks and their correlation simultaneously by a multiple frequency task labeling technique. We are currently applying this technique to detect various brain functions, such as numerical calculation, stereopsis, sentence recognition etc. We have detected an activation related to 'willingness' up to now.

Report

(4 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • 1995 Annual Research Report
  • Research Products

    (18 results)

All Other

All Publications (18 results)

  • [Publications] Kazuo Kuwata: "Cross-relaxation times of normal and biochemically induced osteoarthritic rabbit knee cartilages" Jpn.J.of Physiol. 47. 291-297 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kazuo Kuwata: "Alteration of redox state of human serum albumin in patients under anesthesia and invasive surgery" J.Chromatogr.B. 698. 27-33 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kazuo Kuwata: "Rotational correlation times of internuclear vectors in a DNA duplex with G-A mismatch determined in aquccus solution by complete relaxation matrix analysis of off-resonance ROESY (0-ROESY) sprctra" J.Magn.Reson.128. 70-81 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kazuo Kuwata: "High level expression of bovine β-Lactoglobulin in Pichia pastoris and characterization of its physical properties" Prot.Eng.in press.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kazuo Kuwata: "Clinical applicability of functional magnetic resonance imaging and activation study with single photon emission computerized tomography for functional mapping" Neurol.Res.in press. 20.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 桑田 一夫: "タンパク質のかたちと物性" 共立出版, 234 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Kuwata, S.Sato, S.Era, M.Sogami, K.Kida, T.Iwama, K.Kato, T.Matsunaga and H.Watari: "Cross-relaxation times of normal and biochemically induced osteoarthritic rabbit knee cartilages" Jpn.J.of Physiol.47. 291-297 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] A.Hayakawa, K.Kuwata, S.Era, M.Sogami, H.Shimonaka, M.Yamamoto, S.Dohi and H.Hirose: "Alteration of redox state of human serum albumin in patients under anesthesia and invasive surgery" J.Chromatogr.B 698. 27-33 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Kuwata, H.Liu, T.L.James and T.Schleich: "Rotational correlation times of internuclear vectors in a DNA duplex with G-A mismatch determined in aqueous solution by complete relaxation matrix analysis of off-resonance ROESY (O-ROESY) spectra" J.Magn.Reson.128. 70-81 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] T.R.Kim, Y.Goto, N.Hirota, K.Kuwata and C.A.Batt: "High level expression of bovine beta-Lactoglobulin in Pichia pastoris and characterization of its physical properties" Prot.Eng. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] A.Okumura, K.Kuwata, Y.Nishimura, M.Kawaguchi, K.Takenaka, N.Sakai, S.Era and H.Hoshi: "Clinical applicability of functional magnetic resonance imaging and activation study with single photon emission computerized tomography for functional mapping" Neurol.Res.20. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kazuo Kuwata: "Cross-relaxation times of normal and biochemically induced osteoarthritic rabbit knee cartilages" Jpn.J.of Physiol.47・3. 291-297 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kazuo Kuwata: "Alteration of redox state of human serum albumin in patients under anesthesia and invasive surgery" J.Chromatogr.B. 698. 27-33 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kazuo Kuwata: "Rotational correlation times of internuclear vectors in a DNA duplex with G-A mismatch determined in aqueous solution by complete relaxation matrix analysis of off-resonance ROESY (O-RSFSY) spectra" J.Magn.Reson.128・1. 70-81 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kazuo Kuwata: "High level expression of borine B-Lactoglobulin in Pichia pastoris and characterization of its physical properties" Prot.Eng.in press.

    • Related Report
      1997 Annual Research Report
  • [Publications] 桑田一夫: "タンパク質のかたちと物性" 共立出版, 234 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kazuo Kuwata: "Comparative ^1H-NMR studies on the physical state of water in soft contact lens and mouse lens" Biochim.Biophys.Acta. 1289. 369-376 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kazuo Kuwata: "Spin-lattice relaxation times of water in polarized and depolarized rabbit vagus nerve" Biochem. Biophys. Res. Commun.215. 459-466 (1995)

    • Related Report
      1995 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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