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Long-term potentiation of inhibitory postsynaptic potentials in rat lateral septal nucleus neurons

Research Project

Project/Area Number 07680904
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 神経・脳内生理学
Research InstitutionKurume University

Principal Investigator

HASUO Hiroshi  Kurume Univ. Sch. Med., Associate Professor, 医学部, 助教授 (90172882)

Co-Investigator(Kenkyū-buntansha) TSURUSAKI Masashi  Kurume Univ. Sch. Med., Lecturer, 医学部, 講師 (60207454)
Project Period (FY) 1995 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1996: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1995: ¥1,700,000 (Direct Cost: ¥1,700,000)
KeywordsLTP / GABA receptor / interneuron / IPSP / EPSP / GABA_B / lateral septum / induction / 修飾作用 / 細胞内電位記録
Research Abstract

Intracellular recordings were made from neurons of rat lateral septal nucleus (LSN) in para-sagittal slice preparations which contain both septum and hippocampus. High frequency stimulations (HFS) (100 Hz, n=100,2 trains at 20 s intervals) of fimbria did not produce a long-term potentiation (LTP) of an EPSP but resulted in a LTP of late hyperpolarizing potential (LHP) in the presence of a GABA_A receptor antagonist. The LTP of LHP was blocked by a NMDA receptor antagonist. The monosynaptic LHP did show LTP.These date suggests that the LTP of LHP is mediated by the LTP of EPSP in GABAergic interneurons. In the presence of both GABA_A and GABA_B receptor antagonists, however, the HFS produced a LTP of EPSP.The induction of this LTP was also NMDA receptor-dependent. When a LHP was reduced postsynaptically by injection of Cs-ions the LTP of EPSP was induced in the absence of GABA_B receptor antagonist. While, the LTP of EPSP in the presence of GABA_B receptor antagonist was inhibited by hyperpolarizing DC current during HFS.These data suggest a functional role of GABA_B receptors on the LTP of glutamatergic transmission in principal neurons of rat LSN.

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • Research Products

    (50 results)

All Other

All Publications (50 results)

  • [Publications] Gallagher JP: "Activities of neurons within the rat dorsolateral septal nucleus (DLSN)." Prog Neurobiol. 45. 373-395 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Hasuo H: "Muscarine increases a voltage-independent potassium conductance through an M_4 receptor in rat dorsolateral septal nucleus neurons." Neurosci Lett. 189. 163-166 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Hasuo H: "Does hippocampal long-term potentiation (LTP) spread to neurons in rat dorsolateral septal mucleus?" 4th IBRO Abstr. 200- (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Zheng F: "1S,3R-ACPD-preferring inward current in rat dorsolateral septal neurons is mediated by a novel excitatory amino acid receptor." Neuropharmacology. 34. 905-917 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Akasu T: "Muscarinic receptors mediating inward and outward currents in rat dorsolateral septal neurons." Soc Neurosci Abstr. 21. 2038- (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Hasuo H.: "Muscarine induced inward currents in rat dorsolateral septal nucleus (DLSN) neurons in vitro." Jpn J Physiol. 45. S215- (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tsurusaki M: "Effects of neurosteroids on the dorsolateral septal neuron of rat." Jpn J Physiol. 45. S147- (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 蓮尾博: "ラット脳背外側中隔核ニューロンにおける過分極性マスカリン応答の解析." Neurosciences. 21. S207-S210 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 蓮尾博: "ラット脳背外側中隔核ニューロンにおけるカルシウムチャネルの多様性." 日本生理誌. 58. 30- (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Hasuo H: "Muscarinic receptor subtypes mediating the inward and outward currents in rat dorsolateral septal nucleus neurons." Neurosci Res. Suppl.20. 36- (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tsurusaki M: "The inhibitory actions of aglycemia in rat dorsolateral septum nucleus neurons." Neurosci Res. Suppl.20. 43- (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Hasuo H.: "GABA_B receptor mediated suppression of induction of long-term potentiation (LTP) in rat lateral septal nucleus neurons." Soc Neurosci Abstr. 22. 1506 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Akzsu T: "Depletion of glucose causes presynaptic inhibition of neuronal transmission in the rat dorsolateral septal nucleus." Synapse. 24. 125-134 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Hasuo H: "Muscarine activates a nonselective cation current a M_3 muscarinic receptor subtype in rat dorsolateral septal nucleus neurons." J Neurophysiol. 76. 2221-2230 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Hasuo H: "Long term potentiation (LTP) of inhibitory postsynaptic potentials (IPSPs) and excitatory postsynaptic potential s (EPSPs) in rat lateral septal nucleus (LSN) neurons." Jpn J Physiol. 46. S105 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 後藤雅史: "ラット脳背外側中隔核ニューロンにおけるligand-gated K-channelの解析" 日本生理誌. 59(印刷中). (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Xi Z-X: "Baclofen reduces GABA_A receptor responses in acutely dissociated neurons of bullfrog dorsal root ganglia." Synapse. (in press). (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Gallagher JP: "Activities of neurons whthin the rat dorsolateral septal nucleus (DLSN)." Prog Neurobiol. 45 (5). 373-395 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Hasuo H: "Muscarine increases a voltage-independent potassium conductance through an M_4 receptor in rat dorsolateral septal nucleus neurons." Neurosci Lett. 189 (3). 163-166 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Hasuo H: "Does hippocampal long-term potentiation (LTP) spread to neurons in rat dorsolateral septal nucleus?" 4th IBRO Abstr. 200 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Zheng F: "1S,3R-ACPD-preferring inward current in rat dorsolateral septal neurons is mediated by a novel excitatory amino acid receptor." Neuropharmacology. 34 (8). 905-917 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Akasu T: "Muscarinic receptors mediating inward and outward currents in rat dorsolateral septal neurons." Soc Neurosci Abstr. 21 (3). 2038 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Hasuo H: "Muscarine induced inward currents in rat dorsolateral septal nucleus (DLSN) neurons in vitro." Jpn J Physiol. 45 (Suppll). 125 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tsurusaki M: "Effects of neurosteroids on the dorsolateral septal neuron of rat" Jpn J Physiol. 45 (Suppll). 147 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Hasuo H: "Muscarinic receptor subtypes mediation the inward and outward currents in rat dorsolateral septal nucleus neurons." Neurosci Res. (Suppl 20). 36 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tsurusaki M: "The inhibitory actions of aglycemia in rat dorsolateral septum nucleus neurons." Neurosci Res. (Suppl 20). 43 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Hasuo H: "GABA_B receptor mediated suppression of induction of long-term potentiation (LTP) in rat lateral septal nucleus neurons." Soc Neurosci Abstr. 22 (2). 1506 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Akasu T: "Depletion of glucose causes presynaptic inhibition of neuronal transmission in the rat dorsolateral septal nucleus." Synapse. 24 (2). 125-134 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Hasuo H: "Muscarine activates a nonselective cation current through a M_3 muscarinic receptor subtype in rat dorsolateral septal nucleus neurons." J Neurophysiol. 76 (4). 2221-2230 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Hasuo H: "Long term potentiation (LTP) of inhibitory postsyaptic potentials (IPSPs) and excitatory postaynaptic potentials (EPSPs) in rat lateral septal nucleus (LSN) neurons." Jpn J Physiol. 46 (Suppl). 105 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Xi Z-X: "Baclofen reduces GABA_A receptor responses in acutely dissociated neurons of bullfrog dorsal root ganglia." Synapse. (in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Hasuo H: "Muscarinic receptor subtypes mediating the inward and outward currents′ in rat dorsolateral septal nucleus neurons." Neurosci Res. Suppl. 20. 36- (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Tsurusaki M: "The inhibitory actions of aglycemia in rat dorsolateral septum nucleus" Neurosci Res. Suppl. 20. 43- (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Hasuo H: "GABA_B receptor mediated suppression of induction of long-term potentiation (LTP) in rat lateral septal nucleus neurons." Soc Neurosci Abstr. 22 (2). 1506- (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Akasu T: "Depletion of glucose causes presynaptic inhibition of neuronal transmission in the rat dorsolateral septal nucleus." Synapse. 24 (2). 125-134 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Hasuo H: "Muscarine activates a nonselective cation current through a M_3 muscarinic receptor subtype in rat dorsolateral septal nucleus neurons." J Neurophysiol. 76 (4). 2221-2230 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Hasuo H: "Long term potentiation (LTP) of inhivitory postsynaptic potentials (IPSPs) and excitatory postsynaptic potentials (EPSPs) in rat lateral septal nucleus (LSN) neurons" Jpn J Physiol. 46 (Suppl). 105- (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 後藤雅史: "ラット脳背外側中隔核ニューロンにおけるLigand-gated K-channelの解析" 日本生理誌. 59(印刷中). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Xi Z-X: "Baclofen reduces GABA_A receptor responses in acutely dissociated neurons of bullfrog dorsal root ganglia." Synapse. (in press). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] 鶴岡政志: "ラット中隔核ニューロンに於ける細胞外無グルコースの抑制作用." 日本生理誌. 57. 153- (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Gallagher, J. P.: "Activities of neurons within the rat dorsolateral septal nucleus (DLSN)." Prog. Neurobiol.45. 373-395 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Hasuo, H.: "Muscarine increases a voltage-independent potassium conductance through an M_4 receptor in rat dorsolateral septal nucleus neurons." Neurosci. Lett.189. 163-166 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Hasuo, H.: "Does hippocampal long-term potentiation (LTP) spread to neurons in rat dorsolateral septal nucleus?" 4th IBRO Abstr.200- (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Zheng, F.: "1S, 3R-ACPD-preferring inward current in rat dorsolateral septal neurons is mediated by a novel excitatory amino acid receptor." Neuropharmacology. 34. 905-917 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Akasu, T.: "Muscarinic receptors mediating inward and outward currents in rat dorsolateral septal neurons." Soc. Neurosci. Abstr.21. 2038- (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Hasuo, H.: "Muscarine induced inward currents in rat dorsolateral septal nucleus (DLSM) neurons in vitro." Jpn. J. Physiol.45 Suppl. 1. 125- (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Tsurusaki, M.: "Effects of neurosteroids on the dorsolateral septal neuron of rat." Jpn. J. Physiol.45 Suppl. 1. 147- (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 蓮尾 博: "ラット脳背外側中隔核ニューロンにおける過分極性マスカリン応答の解析." Neurosciences. 21 Suppl. 2. 207-210 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 蓮尾 博: "ラット脳背外側中隔核ニューロンにおけるカルシウムチャネルの多様性." 日本生理誌. 58. 30- (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Akasu, T.: "Depletion of glucose causes presynapic inhibition of neuronal transmission in the rat dorsolateral septal nucleus." Synapse. (in press). (1996)

    • Related Report
      1995 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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