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Localization and function of acidic fibroblast growth factor in adrenal gland

Research Project

Project/Area Number 07807002
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General anatomy (including Histology/Embryology)
Research InstitutionShiga University of Medical Science

Principal Investigator

TOOYAMA Ikuo  Shiga University of Medical Science Associate Professor., 分子神経生物学研究センター, 助教授 (20207533)

Project Period (FY) 1995 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1996: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1995: ¥800,000 (Direct Cost: ¥800,000)
KeywordsAcidic fibroblast growth factor / FGF / receptor / hormone / adrenal gland / PCR / 免疫組織化学
Research Abstract

Fibroblast growth factor (FGF) is a family of peptides which promote the proliferation of mesodermal tissues and neuroectodermal cells. Acidic fibroblast growth factor (aFGF ; FGF-1) and basic fibroblast growth factor (bFGF ; FGF-2) were first members of this family that were purified and well characterized. The distribution of aFGF was originally through to be limited to the central nervous system such as the brain and retina. The present studies however, have demonstrated that aFGF mRNA is richly exoressed in the adrenal medulla, and aFGF peptide is localized in adrenergic neurons. Moreover, FGF receptor-1 has been detected in the adrenal cortex. Administration of FGF has upragulated the secretion of adrenocortical steroid hormones. These results suggest that aFGF may regulate the secretion of adrenal steroids as a local hormone.
In addition, aFGF exogenously administered has several effects on physiological behaviors. These include supression of food intake and the improvement of memory and learning. Taken together, it is strongly suggested that aFGF may exert its biological activity, at least partly, as a hormone.

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • Research Products

    (19 results)

All Other

All Publications (19 results)

  • [Publications] K Sasaki et al.: "Actions of acidic fibroblast growth factor fragments on food intake in rats." Obesity Rescarch. 3 (Supple 5). 697-706 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] A. Hamaguchi et al.: "Demonstration of fibroblast growth factor receptor-I in human prostate by polymerase chain reaction and immunohistochemistry." Prostate. 27. 141-147 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] A-J Li et al.: "Fibroblast growth factor receptor-I in the lateral hypothalamic area regulates food intake." Experimental Neurology. 137. 318-323 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y Oomura et al.: "Protection against impairment of memory and immunoreactivity in senescence-accelerated mice by acidie fibroblast growth factor." Ann New Yolk Acad Sci. 786. 337-347 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y Takeichi et al.: "Basic FGF partially prevents degeneration of paraventricular vaopressin neurons after hypophysectomy." Restor Neurol Neurosci. 10. 161-166 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] I Tooyama et al.: "Fffect of acidic fibroblast grwoth factor on basal forebrain cholinergic neurons in senescenc-aecelerated mine." Experimental Gerontology. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] K Sasaki, Y Oomura, A-J Li, K Hanai, I Tooyama, H Kimura, N Yanaihara, T Hori: "Actions of acidic fibroblast growth factor fragments on food intake in rats." Obesity Res. 3 (Supple 5). 697S-706S (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] A.Hamaguchi, I.Tooyama, T.Yoshiki, H.Kimura: "Demonstration of fibroblast growth factor receptor-I in human prostate by polymerase chain reaction and immunohistochemistry." Prostate. 27. 141-147 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] A-J Li, Y Oomura, T Hori, S Aou, K Sasaki, H Kimura, I Tooyama: "Fibroblast growth factor receptor-I in the lateral hypothalamic area regulates food intake." Exp Neurol. 137. 318-323 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y Oomura, K Sasaki, A Li, H Yoshii, Y Fukata, H Yago, H Kimura, I Tooyama, K Hanai, Y Nomura, N Yanaihara: "Protection against impairment of memory and immunoreactivity in senescence-accelerated mice by acidic fibroblast growth factor." Ann New York Acad Sci. 786. 337-347 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y Takeichi, Y Nakasu, I Tooyama, H Kimura: "Basic FGF partially prevents degeneration of paraventricular vaopressin neurons after hypophysectomy." Restor Neurol Neurosci. 10. 161-166 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] I Tooyama, K Sasaki, Y Oomura, A-J Li, H Kimura: "Effect of acidic fibroblast grwoth factor on basal forebrain cholinergic neurons in senescenc-accelerated mice." Exp Gerontol. 7(in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] K Sasaki et al.: "Actions of acidic fibroblast growth factor fragments on food intake in rats." Obesity Research. 3(Supple5). 697-706 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] A.Hamaguchi et al.: "Demonstration of fibroblast growth factor receptor-I in human prostate by polymcrase chain reaction and immunohistochemistry." Prostate. 27. 141-147 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] A-J Li et al.: "Fibroblast growth factor receptor-I in the lateral hypothalamic area regulates food intake." Experimental Neurology. 137. 318-323 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Y Oomura et al.: "Protection against impairment of memory and immunoreactivity in senescence-accelerated mice by acidic fibroblast growth factor." Ann New Yolk Acad Sci. 786. 337-347 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Y Takeichi et al.: "Basic FGF partially prevents degeneration of paraventricular vaopressin neurons after hypophysectomy." Restor Neurol Neurosci. 10. 161-166 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] I Tooyama et al.: "Effect of acidic fibroblast grwoth factor on basal forebrain cholinergic neurons in senescenc-accelerated mice." Experimental Gerontology. (in press).

    • Related Report
      1996 Annual Research Report
  • [Publications] Ikuo Tooyama: "Effect of acidic fibroblast growth factor on basal forebrain cholinergic neurons in senescence accelerated mice" Experimental Gerontology. (発表予定). (1996)

    • Related Report
      1995 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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