| Project/Area Number |
07807040
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Kyushu University |
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Principal Investigator |
MAKITA Yuji Kyushu University, Faculty of Medicine Associate Professor, 医学部, 助教授 (30209407)
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| Co-Investigator(Kenkyū-buntansha) |
OMURA Minoru Kyushu University, Faculty of Medicine Assistant, 医学部, 助手 (50243936)
HIRATA Miyuki Kyushu University, Faculty of Medicine Assistant, 医学部, 助手 (30156674)
TANAKA Akiyo Kyushu University, Faculty of Medicine Assistant Professor, 医学部, 講師 (10136484)
INOUE Naohide Kyushu University, Faculty of Medicine Professor, 医学部, 教授 (00131904)
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| Project Period (FY) |
1995 – 1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1996: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1995: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | Trace element / Chronic renal failure / Hemodialysis / Distribution / Animal experiment / Wistar rat / 動物実験(ラット・ハムスター) / 生体内動態 / 尿毒症 |
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| Research Abstract |
Biologic roles and distributions of trace elements such as aluminium, arsenic, selenium, copper, zinc, chrome or manganese were investigated in hemodialysis patients and Wistar rat. Effects of serum aluminium and iron on bone turnover were studied by evaluating serum high sensitive parathyroid hormone (HS-PTH) and alkaline phosphatarse (ALP). The elevation of serum aluminium concentration induced an increase of HS-PTH and decrease of ALP.It is considered that substantial bone formation is inhibited, although HS-PTH stimulates it. On the contrary, serum iron scarcely affected bone formation and metabolism.
Long term follow-up study of a hemodialysis patient with total parenteral nutrition revealed the lack of many trace elements such as copper, selenium, zinc and lead. Especially, the lack of copper or selenium was evident but clinical manifestations based on the lack of these trace elements were not observed during follow-up period (8 years). These findings might suggest the compatibility of trace elements or existence of buffer system minimizing lack of trace elements.
Serum concentrations of trace elements including iron, zinc, copper and arsenic were investigated in Wistar rats. They are maintained strictly constant more than 1 year long and distributed mainly in the blood, liver, kidney and spleen.
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