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A case-control study on alcohol drinding habit, ALDH2 genotype and colorectal cancer.

Research Project

Project/Area Number 07807043
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionCHIBA CANCER CENTER RESEARCH INSTITUTE

Principal Investigator

MURATA Motoi  CHIBA CANCER CENTER RESEARCH INSTITUTE, 研究局・疫学研究部, 部長 (90260257)

Co-Investigator(Kenkyū-buntansha) WATANABE Satoshi  CHIBA CANCER CENTER RESEARCH INSTITUTE, 消化器外科, 主任医長
Project Period (FY) 1995 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1997: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1996: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1995: ¥700,000 (Direct Cost: ¥700,000)
Keywordscolorectal cancer / alcohol drinking habit / ALDH2 genotype
Research Abstract

A case-control study was conducted to explore a possible etiological role of alcohol drinking habit in colorectal cancer. Cases were 243 colon and 147 rectum cancer patients who were surgically treated in Chiba Cancer Center Hospital during the period 1989 through 1997. Controls were 1,124 persons including both patients of benign diseases and attendants of a health check program. Information on their life styles such as drinking, smoking and dietary habits was collected by a self-administered questionnaire. For a part of them (210 cases and 303 controls), alcohl tolerance was also checked by a DNA test of ALDH2 genotypes with the PCR method. Japanese population shows inter-individual variation of aldehyde dehydrogenase activity due to a polymorphism of this gene, with alcohol tolerant 1/1 homozygotes, intermediate 1/2 heterozygotes and intolerant 2/2 homozygotes.
According to a uni-variate analysis with the chi-square statistical test, the factors such as daily amount of alcohol consumption, frequent intake of meat, and irregular, hastened and excess meal habits were all significantly associated with both colon and rectum cancers, whereas infrequent intake of milk and fish was associated only with rectum cancer. Daily amount of tobacco smoked, intake frequency of fruits and vegetables were not different between cases and controls. These results remained unchanged even after a multi-variate logistic regression analysis was performed. If the ALDH2 genotype was included in the multi-variate analysis, this genotype instead of alcohol consumption showed signficant association with colon cancer, indicating that reduced enzyme activity in the heterozygotes is a risk factor for colon cancer. This is most prominent for sigmoid colon cancer. No such relation was found for rectum cancer. It is concluded that excess alcohl drinking is a risk factor for colorectal cancer and that the heterozygotes of ALDH2 are especially a high-risk group for colon cancer.

Report

(4 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • 1995 Annual Research Report
  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] Motoi Murata et al.: "Analysis of a germline polymorphism of tje p53 gene in lung cancer patients;discrete results with smoking history." Carcinogenesisi. 17(2). 261-264 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Motoi Murata et al.: "A nested case-control study on alcohol drinking,tabacco smoking,and cancer." Cancer Detect.& Prev. 20. 557-565 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Motoi Murata et al.: "Correlation of the mutation of p53 gene and the polymorphism at codon 72 in smoking-related non-small cell lung cancer patients." International Journal of Oncology. 12. 577-581 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Murata, M., Tagawa, M., Kimura, M., Kimura, H., Watanabe, S.and Saisho, H.: "Analysis of a germline polymorphism of the p53 gene in lung cancer patients ; descrete results with smoking history." Carcinogenesis. 17 (2). 261-264 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Murata, M., Takayama, K., Choi, BCK.and Pak, AWP.: "Anested case-control study on alcohol drinking, tobacco smoking, and cancer." Cancer Detect.& Prev.20 (6). 557-565 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Murata, M., Tagawa, M., Kimura, H., Kakisawa, K., Shirasawa, H.and Fujisawa, T.: "Correlation of the mutation of p53 gene and the polymorphism at codon 72 in smoking-related non-small cell lung cancer patients." Int.J Oncology. 12 (2). 577-581 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Motoi Murata et al.: "A nested case-control study on alcohol drinking,tabacco smoking,and cancer." Cancer Detect.& Prev.20. 557-565 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Motoi Murata et al.: "Correlation of the mutation of P53 Gene and the polymorphism at codon 72 in smoking-related non-small cell lung cancer patients." International Journal of Oncology. 12. 577-581 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Motoi Murata et al.: "A nested case-control study on alcohol drinking,tabacco smoking,and cancer." Cancer Detect.& Prev.20. 557-565 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Motoi Murata et al.: "Analysis of a germ line polymorphism of the p53 gebe in lung cancer patients; discrete results with smoking history." Carcinogenesis. 17. 261-264 (1996)

    • Related Report
      1995 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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