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A study on altered immune function in rheumatoid arthritis through disfunction of transcription factor

Research Project

Project/Area Number 07807051
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 内科学一般
Research InstitutionUniversity of Tokyo

Principal Investigator

INOUE Tetsufumi  University of Tokyo, Department of Medicine, Associate Professor, 医学部・附属病院, 講師 (30092141)

Co-Investigator(Kenkyū-buntansha) SAWADA Tetsuji  University of Tokyo, Department of Medicine, Clinical Fellow, 医学部・附属病院, 医員 (50235470)
TOHMA Shigeto  University of Tokyo, Department of Medicine, Assistant Professor, 医学部・附属病院, 助手 (50207528)
Project Period (FY) 1995 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1996: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1995: ¥1,300,000 (Direct Cost: ¥1,300,000)
Keywordsapoptosis / transcripton factor / reactive oxygen species / anti-rheumatic drugs
Research Abstract

NF-KB is known to play a important role in the regulation of macrophages. It is partially regulated by redox mechanism. In this study, anti-rheumatic drugs, D-penicillamine, bucillamine, auranofine increased the amount of intracellular reactive oxygen species of THP-1, moreover, downregulated their proliferation. It was suggested that these drugs suppressed the activity of NF-KB through the increase of reactive oxygen species.
Possibility of the apoptosis induction through the increase of intracelllar reactive oxygen species was also studied. Bucillamine first induced the production of reactive oxygen species and the change of membrane permeability of THP-1. Consequently, apoptosis of THP-1 turned out. It was suggested that bucillamine suppressed the proliferation of synovial cells in rheumatoid arthritis through the induction of apoptosis.

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • Research Products

    (9 results)

All Other

All Publications (9 results)

  • [Publications] Shinohara,Satoshi: "Differential expression of Fas antigen and Bci-2 protein on CD4^+ T cells,CD8^+ T cells and monocyres." Cellular Immunology. 163. 303-308 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Sawada,Tetsuji: "Generation of reactive oxygen species is required for bucillamine,a novel anti-rheumatic drug,to induce apoptosis in concert with copper." Immunopharmacology. 35. 195-202 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 広畑俊成: "インドメタシンファルネシルと慢性関節リウマチ患者末梢血単核球の相互作用" 日本臨床免疫学会会誌. 19. 136-144 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Shinohara, S., Sawada, T., Nishioka, Y., Tohma, S., Kisaki, T., Inoue, T., et. al.: "Differential expression of Fas antigen and Bcl-2 protein on CD4^+ T cells, CD8^+ T cells and monocytes." Cellular Immmunol.163. 303-308 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Sawada, T., Hashimoto, S., Hurukawa, H., Tohma, S., Inoue, T., Ito, K.: "Generation of reactive oxygen species is required for bucillamine, a novel anti-rheumatic drug, to induce apoptosis in concert with copper." Immunopharmacology. 35 (3). 195-202 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Hirohata, S., Konuma, K., Inoue, T.: "Interaction of indomethacine farnecil with mononuclear cells from patients with rheumatoid arthritis." J.Japanese Soc. Clin. Immunol.19. 136-144 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Sawada,Tetsuji: "Generation of reactive oxygen species is required for bucillamine,a novel anbi-rheumatic drug,to induce apoptosis in concert with copper." Immunopharmacology. 35・3. 195-202 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 広畑俊成: "インドメタシンファルネシルと慢性関節リウマチ患者末梢血単核球の相互作用" 日本臨床免疫学会会誌. 19・2. 136-144 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Shinohar,Satoshi: "Differential expression of Fas antigen and Bcl-2 protein on CD4_<1+>T cells,CD8_<1+>T cells and monooytes." Cellular Immunol.163. 303-308 (1995)

    • Related Report
      1995 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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